TY - JOUR AU - Stadnik, S.M. PY - 2022/07/06 Y2 - 2024/03/29 TI - Features of APOE polymorphism in patients with arrhythmias depending on the severity of cognitive disorders JF - INTERNATIONAL NEUROLOGICAL JOURNAL JA - INJ VL - 18 IS - 2 SE - Original Researches DO - 10.22141/2224-0713.18.2.2022.936 UR - https://inj.zaslavsky.com.ua/index.php/journal/article/view/936 SP - 4-9 AB - <p>Carriers of APOE4 polymorphism are at increased risk of cognitive decline. The purpose of this work was to investigate the relationship between genetic (APOE gene polymorphism) indicators and the development of cognitive disorders in patients with arrhythmias. <strong>Materials and methods.</strong> A comparative analysis of the frequency of genotypes and alleles of polymorphic variants of the APOE gene was conducted. It involved 110 patients aged from 30 to 75 years (mean age 63.8 ± 4.3 years): the basic group included 86 individuals with cognitive disorders on the background of different forms of arrhythmias and the control group consisted of 24 patients with arrhythmia without cognitive impairment. <strong>Results.</strong> The predominance of ε3/ε3 genotype was found in 57 % of people with cognitive disorders and in 54.2 % without cognitive decline (p = 0.07). The least common was ε4/ε4 genotype, the frequency of which in cognitive impairment was 5.8 %; in patients without cognitive disorders, it was not detected at all (p &lt; 0.001). Among heterozygous genotypes, ε3/ε4 was found in 19.8 % of patients with cognitive disorders and in 16.6 % without cognitive decline (p = 0.06); ε2/ε3 — in 11.6 and 20.8 % (p = 0.026), respectively. Individuals with mild cognitive impairment tended to accumulate genotypes ε2/ε3, ε3/ε3 and decrease genotypes ε2/ε4, ε3/ε4, which did not reach the level of statistical significance compared to those without cognitive disorders (p = 0.06). Among patients with moderate cognitive impairment, there were no carriers of ε2/ε2 and ε2/ε3 genotypes, and the frequency of carriers of ε3/ε4, ε4/ε4 genotypes (p = 0.034) increased. <strong>Conclusions.</strong> Carriage of the ε4 APOE allele is an additional factor that increases the risk of cognitive disorders in patients with arrhythmias, carriage of the ε2 allele can be considered a protective factor against the development of cognitive impairment.</p> ER -