TY - JOUR AU - Trepet, H.S. AU - Trepet, L.M. AU - Havryliuk, Ya.A. PY - 2021/11/15 Y2 - 2024/03/29 TI - Ischemic stroke as a consequence of coagulopathy in coronavirus disease JF - INTERNATIONAL NEUROLOGICAL JOURNAL JA - INJ VL - 17 IS - 2 SE - Original Researches DO - 10.22141/2224-0713.17.2.2021.229891 UR - https://inj.zaslavsky.com.ua/index.php/journal/article/view/862 SP - 25-30 AB - <p><em><strong>Objective:</strong></em> to compare the state of the coagulation system in patients with ischemic stroke and coronavirus disease in those with ischemic stroke without coronavirus disease. <em><strong>Materials and methods.</strong> </em>We examined 40 patients in the acute period of cerebral ischemic stroke, aged from 69 to 87 years (average age of 77.30 ± 2.08 years). They were divided into two groups: group I — SARS-CoV-2-positive, group II — SARS-CoV-2-negative. Group I consisted of 20 individuals (9 women and 11 men) aged 69 to 84 years (average age of 76.9 ± 3.0 years). Group II included 20 patients (10 women and 10 men) aged 72 to 87 years (average age of 78.5 ± 2.5 years). <em><strong>Results.</strong> </em>Twelve (60 %) patients of group I had a moderate disease severity, 8 (40 %) — severe. The severity of neurologic deficits on the National Institutes of Health Stroke Scale did not differ significantly in patients of both clinical groups: in group I it was 14.0 ± 0.7 points, in group II — 10.00 ± ± 1.37 points, which corresponded to moderate stroke, the significance level p = 0.05. In the neurological status, motor and sensory deficits were observed in both groups in combination with speech disorders and ataxia. The average level of prothrombin index in group I was 101 ± 6 %, in II — 83 ± 2 %, p = 0.01. The level of fibrinogen in group I was 401.0 ± 18.6 mg/dl, in group II — 250 ± <br />± 12 mg/dl, which can lead to temporary hypercoagulation and the development of thromboembolism (p &lt; 0.05). In group I, the level of D-dimer was 465 ± 8 ng/ml, in group II — 175 ± 4 ng/ml <br />(p &lt; 0.05). <em><strong>Conclusions.</strong> </em>The data suggest that SARS-CoV-2-posi-tive patients with ischemic stroke compared to SARS-CoV-2-ne-gative ones with ischemic stroke are characterized by the presence of coagulopathy, as evidenced by significantly higher levels of fibrinogen, prothrombin index, D-dimer and moderate thrombocytopenia, as well as significantly higher levels of C-reactive protein that indicates the presence of an acute inflammatory process, which also causes thrombosis.</p> ER -