Levetiracetam is a modern solution to the problem of epilepsy in neuropediatric practice

Authors

  • L.B. Maryenko Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
  • K.M. Marienko Danylo Halytsky Lviv National Medical University, Lviv, Ukraine

DOI:

https://doi.org/10.22141/2224-0713.18.1.2022.930

Keywords:

levetiracetam, epilepsy, seizures, children

Abstract

Levetiracetam is an antiepileptic drug, which has a fundamentally different mechanism of action among all drugs in this group. In vitro studies have shown that levetiracetam binds to the synaptic vesicles glycoprotein 2A contained in the gray matter of the brain and spinal cord. Thus, it affects the intraneuronal concentration of Ca2+ ions, partially inhibiting the Ca2+ flow through N-type channels and reducing the release of calcium from intraneuronal depots. In addition, levetiracetam partially restores flow through GABA- and glycine-dependent channels reduced by zinc and β-carbolines. Due to this, leviteracetam inhibits excessive neuronal synchronization and has an anticonvulsant effect. In neuropediatric practice, there is evidence that levetiracetam may be used as monotherapy to treat focal seizures with or without bilateral tonic-clonic seizures, as well as adjunctive therapy for myoclonic seizures in patients with juvenile myoclonic and idiopathic generalized epilepsy. At the same time, levetiracetam is characterized by rapid achievement of therapeutic effect and good tolerability in children and adolescents, as proven in many randomized clinical trials.

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Published

2022-03-31

How to Cite

Maryenko, L., & Marienko, K. (2022). Levetiracetam is a modern solution to the problem of epilepsy in neuropediatric practice. INTERNATIONAL NEUROLOGICAL JOURNAL, 18(1), 54–62. https://doi.org/10.22141/2224-0713.18.1.2022.930

Issue

Section

Original Researches