Nervous system disorders in a patient with Adie syndrome (a clinical case)


  • A.L. Sidelkovskiy Clinic of Modern Neurology “Aksimed”, Kyiv, Ukraine



Adie syndrome, mydriasis, ciliary ganglion, autonomic dysfunction, parasympathetic innervation, accommodation


Holmes-Adie syndrome, or tonic pupil syndrome, is a condition characterized by a triad of main symptoms: unilateral tonic pupil dilation, accommodative paresis without or with a significant reduction in pupillary light reflex, and decreased tendon reflexes. The disease is based on dysfunction of the parasympathetic nervous system. The syndrome results from damage to the ciliary ganglion, which carries parasympathetic innervation to the m.sphincter pupillae, cornea, and eyeball. Often the condition is accompanied by dysfunction of the spinal ganglia and, as a consequence, autonomic dysfunction in the form of sweating disorders, usually on one side of the body, rarely — by heart rhythm disorders, lability of blood pressure. A frequent sign of Adie syndrome is the absence or reduction in patellar, rarely Achilles, reflexes. The etiology of the disease is not definitively determined, bacterial or viral factors are not excluded. The diagnosis of Adie syndrome is mainly based on a clinical comparison of the symptoms of the disease, as well as on a thorough and comprehensive examination by a neuroophthalmologist with mandatory testing of pupillary responses with low doses of pilocarpine (narrowing of the pupil is characteristic). Despite the positive prognosis for the patient’s life and his ability to work, the condition belongs to the group of difficult-to-treat ones, and the management consists in symptomatic vision correction.


Download data is not yet available.


Бушуева Н.Н., Храменко Н.И., Бойчук И.М., Шакир М.Х. Духайр. Анизокория при синдроме Holmes-Adie. Загальна патологiя і патологiчна фiзiологiя. 2010. № 3.

Евтушенко С.К. Орфанные заболевания в практике невролога. К., 2020. 95 с.

Пономарчук В.С., Бушуева Н.Н., Храменко Н.И., Решетняк В.Б. Функциональное состояние зрительного анализатора при синдроме Эди. Офтальмологический журнал. 2012. № 6. С. 127-130.

Скоромец А.А., Скоромец А.П., Скоромец Т.А. Топическая диагностика заболеваний нервной системы: руководство для врачей. 8-е издание, перераб. и доп. СПб.: Политехника, 2012. 623 с.

Bell R.A., Тompson H.S. Ciliary muscle dysfunction in Adie’s syndrome. Arch. Opthalmol. 1978. Apr. 96(4). Р. 638-42.

Ulrich J. Morphological basis of Adie’s syndrome. Eur. Neurol. 1980. Vol. 19(6). P. 390-5.



How to Cite

Sidelkovskiy, A. (2022). Nervous system disorders in a patient with Adie syndrome (a clinical case). INTERNATIONAL NEUROLOGICAL JOURNAL, 17(7), 36–38.



Case report

Most read articles by the same author(s)