Clinical neuroimaging correlations in multiple sclerosis

Authors

  • R.K. Shiraliyeva Azerbaijan State Advanced Training Institute for Doctors named after A. Aliyev, Baku, Azerbaijan
  • A.H. Mirzayev Azerbaijan State Advanced Training Institute for Doctors named after A. Aliyev, Baku, Azerbaijan

DOI:

https://doi.org/10.22141/2224-0713.16.7.2020.218250

Keywords:

multiple sclerosis, brain atrophy, clinical features, correlation

Abstract

Background. The purpose was to study the correlation between morphometric indicators оf brain atrophy and clinical symptoms in multiple sclerosis (MS). Materials and methods. Eighty-eight patients (58 women, 30 men) with MS aged 18 to 60 years were under observation. Fifty-six patients had relapse-remitting multiple sclerosis (RRMS), 32 patients had a seconda-ry progressive multiple sclerosis (SPMS). All patients underwent magnetic resonance imaging with voxel-based morphometry. Results. A positive correlation (r = 0.44; p ˂ 0.01) was found between the duration of the disease and the degree of focal brain damage in RRMS; it was noted that the size of the foci increases with increasing duration of the disease. A similar relationship has been established in patients with SPMS. No correlation was found between the degree of focal brain damage in RRMS and SPMS, including the degree of disability with active foci absorbed by a contrasting substance. Conclusions. In MS patients, despite pronounced changes in white matter, the degree of disability depends on the severity of brain atrophy and is not related to the volume of focal lesion. There are significant relationships between morphometric indicators of atrophy of the gray and white matter of the brain and the degree of disability and functional impairment in RRMS and SPMS.

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Published

2021-11-15

How to Cite

Shiraliyeva, R., & Mirzayev, A. (2021). Clinical neuroimaging correlations in multiple sclerosis. INTERNATIONAL NEUROLOGICAL JOURNAL, 16(7), 78–82. https://doi.org/10.22141/2224-0713.16.7.2020.218250

Issue

Section

To practicing Neurologist