A Meta-Analysis of the Results of Clinical Studies on the Efficacy and Tolerability of L-Lysine Aescinat in the Treatment of Traumatic Brain Injury and Acute Cerebrovascular Diseases

Authors

  • L.A. Dziak Dnipropetrovsk State Medical Academy, Dnipropetrovsk
  • A.H. Sirko Dnipropetrovsk State Medical Academy, Dnipropetrovsk

DOI:

https://doi.org/10.22141/2224-0713.6.76.2015.78073

Keywords:

traumatic brain injury, treatment, basic therapy, L-Lysine Aescinat

Abstract

The article deals with the treatment of patients with traumatic brain injury and acute cerebrovascular accidents. A meta-analysis of clinical studies on the efficacy and safety of L-Lysine Aescinat in these patients is provided. The meta-analysis included results of 12 studies involving 1,728 patients of all age groups, of which 727 persons received L-Lysine Aescinat, solution for injection, in addition to the basic therapy. The following parameters were evaluated: changes in intracranial pressure (ICP); changes by the NIHSS; changes according to Glasgow Coma Scale (GCS); Glasgow Outcome Scale; mortality. It has been found that in patients treated with L-Lysine Aescinat, ICP decreased by an average of 21.87 %, while in patients receiving basic therapy alone, this index decreased only by 6.63 %. Indicators of GCS in the group of L-Lysine Aescinat increased by 66.89 %, while in the group where only basic therapy was administered — by 40.61 %. NIHSS values decreased by 47.10 % when using L-Lysine Aescinat, and when receiving only basic treatment — by 30.15 %. In the group of L-Lysine Aescinat, mortality was 10.75 % less than in patients receiving basic therapy alone.

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Published

2015-10-10

How to Cite

Dziak, L., & Sirko, A. (2015). A Meta-Analysis of the Results of Clinical Studies on the Efficacy and Tolerability of L-Lysine Aescinat in the Treatment of Traumatic Brain Injury and Acute Cerebrovascular Diseases. INTERNATIONAL NEUROLOGICAL JOURNAL, (6.76), 29–39. https://doi.org/10.22141/2224-0713.6.76.2015.78073

Issue

Section

Original Researches