Impact of Drug Therapy on Platelet Functional Activity in Patients with Chronic Brain Ischemia

Authors

  • E.F. Barinov Donetsk National Medical University named after M. Gorkyi
  • Ye.A. Statinova Donetsk National Medical University named after M. Gorkyi
  • S.K. Yevtushenko Donetsk National Medical University named after M. Gorkyi
  • S.A. Mamedalieva Donetsk National Medical University named after M. Gorkyi
  • I.S. Yevtushenko Donetsk National Medical University named after M. Gorkyi

DOI:

https://doi.org/10.22141/2224-0713.6.76.2015.78086

Keywords:

chronic brain ischemia (dyscirculatory atherosclerotic encephalopathy), drug therapy, platelet functional activity

Abstract

Standard drug therapy in the patients with chronic brain ischemia of atherosclerotic genesis (dyscirculatory encephalopathy 1st degree) changes the platelet reactivity to agonists, namely adenosine diphosphate (ADP), adrenaline, platelet activation factor (PAF) that confirms the multiple impact of used drugs on intracellular signal systems of platelet associated with purine Р2Y12- and P2Y1-receptors, PAF-receptors and adrenal receptors α2. If platelets are hyperactive to one or several agonists after the course of in-patient treatment the threat of platelet function, impairment of brain circulation and autoimmune inflammation remains. These pathological processes define the progression of chronic brain ischemia. Platelet hypoactivity to one of the agonists does not exclude maintenance or restoration of platelet prothrombotic activity after treatment, as their functional state is determined by relationship of several receptors bounding ADP, adrenaline and PAF.

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Published

2015-10-10

How to Cite

Barinov, E., Statinova, Y., Yevtushenko, S., Mamedalieva, S., & Yevtushenko, I. (2015). Impact of Drug Therapy on Platelet Functional Activity in Patients with Chronic Brain Ischemia. INTERNATIONAL NEUROLOGICAL JOURNAL, (6.76), 112–120. https://doi.org/10.22141/2224-0713.6.76.2015.78086

Issue

Section

To practicing Neurologist

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