The combination of naproxen with triptans, gabapentin, pregabalin and muscle relaxants

N.K. Svyrydova


Today, as before, the problem of acute and chronic pain: headache (migraine, cluster pain), acute pain in different parts of the back, acute and chronic pain in the lower back (a combination with myofascial syndrome) — remains relevant to the neurologist. There is a lot of data on analgesic effectiveness of a single dose of oral analgesics, but today, there comes to the fore the fast acting analgesics and their possible combinations that lead to effective and durable pain relief, as well as significantly reduce the side effect of the maximum dose of a single drug. It is proposed to assess the possibility of a combination of non-steroidal anti-inflammatory agent naproxen with other drugs, such as triptans, gabapentin, pregabalin, muscle relaxants. We have evaluated the possibility of reducing the doses in combination to decrease the risk of side effects in patients with comorbid disorders.


naproxen; combination; gabapentin; pregabalin; triptans; muscle relaxants


Angiolillo D.J., Weisman S.M.Clinical Pharmacology and Cardiovascular Safety of Naproxen // Am. J. Cardiovasc. Drugs. — 2016 Nov 8.

Lily P. Sumatriptan/Naproxen Sodium: A Review of Its Use in Adult Patients with Migraine / H. Yang. — Springer International Publishing Switzerland, 2013.

Treximet (sumatriptan and naproxen sodium) tablets: US prescribing information / GlaxoSmithKline. — Accessed 5 Dec 2012.

Law S. Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults (Review) / Derry S., Moore R.A. // Cochrane Database of Systematic Reviews. — 2016. — Issue 4. —

No.: CD008541.

Angiolillo D.J. Clinical Pharmacology and Cardiovascular Safety of Naproxen / Dominick J. Angiolillo, Steven M. Weisman // American Journal of Cardiovascular Drugs. — 2016 Nov. — 8. — Р. 1-11.

Rostam A. Canadian consensus guidelineson long-term nonsteroidal anti-inflammatory drug therapy and the need for gastroprotection: benefits versus risks / Moayyedi P., Hunt R., Canadian Association of Gastroenterology Consensus Group // Aliment Pharmacol Ther. — 2009. — 29. — 481-96.

Weckwerth G.M., Simoneti L.F., Zupelari-Gonçalves P. Efficacy of naproxen with or without esomeprazole for pain and inflammation in patients after bilateral third molar extractions: A double blinded crossover study // Med. Oral Patol. Oral Cir. Bucal. — 2017. — 22(1). — 122-31.

Mehmood Y., Riaz H., Yousaf H. et al. Formulation and in vitro evaluation of colchicines and naproxen sodium sustain release tablets in combination for treatment of gout // Pak. J. Pharm. Sci. — 2016 Sep. — 29(5). — 1579-1586.

Thorlund К., Toor К., Wu P. et al. Comparative tolerability of treatments for acute migraine: A network meta-analys // Cephalalgia. — 2016, August 12.

Hurley R.W., Chatterjea D., Rose Feng M. Gabapentin and pregabalin can interact synergistically with naproxen to produce antihyperalgesia // Anesthesiology. — 2002 Nov. — 97(5). — 1263-73.

Amiri H.R., Mirzaei M., Beig Mohammadi M.T., Tavakoli F. Multi-Modal Preemptive Analgesia With Pregabalin, Acetaminophen, Naproxen, and Dextromethorphan in Radical Neck Dissection Surgery: A Randomized Clinical Trial // Anesth Pain Med. — 2016 Jul 2. — 6(4).

Mustafa Nevzat Ila Sanayii A.S. Thiocolchicoside and non-steroidal anti-inflammatory drug combinations. WO2010120253 A1.

Jain N.K., Kulkarni S.K., Singh A. Modulation of NSAID-induced antinociceptive and anti-inflammatory effects by alpha2-adrenoceptor agonists with gastroprotective effects // Life Sci. — 2002 May 3. — 70(24). — 2857-69.

Hurley R.W. Gabapentin and Pregabalin Can Interact Synergistically with Naproxen to Produce Antihyperalgesia / Robert W. Hurley, Debika Chatterjea, Meihua Rose Feng, Charles P. Taylor, Donna L. Hammond // Anesthesiology. — 2002. — 97. — 1263-73.

Lal R., Sukbuntherng J., Luo W. Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transported prodrug of gabapentin, with naproxen and cimetidine // Br. J. Clin. Pharmacol. — 2010 May. — 69(5). — 498-507.

König H., Heider D., Lehnert T. et al. ESEMeD/

MHEDEA 2000 investigators. Health status of the advanced elderly in six European countries: results from a representative survey using EQ-5D and SF-12 // Health Qual. Life Outcomes. — 2010. — Vol. 8. — P. 143.

Woolf C.J., Salter M.W. Neuronal plasticity: increasing the gain in pain // Science. — 2000. — Vol. 288(5472). — P. 1765-1769.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2018


   Seo анализ сайта