Cerebral Atrophy in Cerebral Small Vessel Disease
The article deals with investigation of probability of cerebral atrophy (CA) formation according to magnetic resonance markers of cerebral small vessel disease (SVD). During the retrospective cohort study of the data from 308 patients aged 50 to 85 years old with cerebral SVD, CA signs were defined in 60 % of patients, with predominance among males (р = 0.00001). Along with that, CA was not associated with the patients’ age, but it was indirectly associated with cerebral SVD. As for quality of cerebral SVD markers, CA had the closest association with leukoareosis (р < 0.0001), whereas as regards quantity — with combination of any 3 of 4 markers (р < 0.0001). The determination of the efficacy of various approaches for predicting the risk of CA by disease markers through a comparative analysis of 4 different designs showed that the use of logit model, we have developed, with a sensitivity of 90.09 % and a specificity of 97.17 % is the most appropriate way of establishing the likelihood of atrophic changes in cerebral SVD.
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