DOI: https://doi.org/10.22141/2224-0713.8.86.2016.90906

Cerebral Atrophy in Cerebral Small Vessel Disease

T.S. Mishchenko, I.M. Nikishkova, V.M. Mishchenko, D.O. Kutikov

Abstract


The article deals with investigation of probability of cerebral atrophy (CA) formation according to magnetic resonance markers of cerebral small vessel disease (SVD). During the retrospective cohort study of the data from 308 patients aged 50 to 85 years old with cerebral SVD, CA signs were defined in 60 % of patients, with predominance among males (р = 0.00001). Along with that, CA was not associated with the patients’ age, but it was indirectly associated with cerebral SVD. As for quality of cerebral SVD markers, CA had the closest association with leukoareosis (р < 0.0001), whereas as regards quantity — with combination of any 3 of 4 markers (р < 0.0001). The determination of the efficacy of various approaches for predicting the risk of CA by disease markers through a comparative analysis of 4 different designs showed that the use of logit model, we have developed, with a sensitivity of 90.09 % and a specificity of 97.17 % is the most appropriate way of establishing the likelihood of atrophic changes in cerebral SVD.


Keywords


cerebral small vessel disease; cerebral atrophy; markers

References


Wardlaw J. Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging / J. Wardlaw, С. Smith, М. Dichgans // Lancet Neurol. — 2013. — ​V. 12. — ​P. 483-497.

Cerebral small vessel disease: Capillary pathways to stroke and cognitive decline / L. Østergaard, T.S. Engedal, F. Moreton et al. // J. Cereb. Blood Flow Metab. — 2016. — ​V. 36, № 2. — ​P. 302-325.

Capillary dysfunction: its detection and causative role in dementias and stroke / L. Østergaard, S.N. Jespersen, T.S. Engedal et al. // Curr. Neurol. Neurosci. Rep. — 2015. — ​V. 15, № 6. — ​P. 37.

Rationale, design and methodology of the image analysis protocol for studies of patients with cerebral small vessel disease and mild stroke / M. del C. Valdés Hernández, P.A. Armitage, M.J. Thrippleton et al. // Brain Behav. — 2015. — ​V. 5, № 12. — ​e00415.

Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden / J. Staals, S.D. Makin, F.N. Doubal et al. // Neurology. — 2014. — ​V. 83, № 14. — ​P. 1228-1234.

Characterising the grey matter correlates of leukoaraiosis in cerebral small vessel disease / C. Lambert, J. Sam Narean, P. Benjamin et al. // Neuroimage Clin. — 2015. — ​V. 9. — ​P. 194-205.

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration / J.M. Wardlaw, E.E. Smith, G.J. Biessels et al. // Lancet Neurol. — 2013. — ​V. 12. — ​Р. 822-838.

Structural network connectivity and cognition in cerebral small vessel disease / А.М. Tuladhar, Е. van Dijk, М.Р. Zwiers et al. // Hum. Brain Марр. — 2016. — ​V. 37, № 1. — ​P. 300-310.

Enlarged perivascular spaces on MRI are a feature of cerebral small vessel disease / F.N. Doubal, A.M. MacLullich, K.J. Ferguson et al. // Stroke. — 2010. — ​V. 41. — ​P. 450-454.

MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging / F. Fazekas, J.B. Chawluk, A. Alavi et al. // AJR Am. J. Roentgenol. — 1987. — ​V. 149. — ​P. 351-356.

Progression of MRI markers in cerebral small vessel disease: sample size considerations for clinical trials / Р. Benjamin, Е. Zeestraten, С. Lambert et al. // J. Cereb. Blood Flow Metab. — 2016. — ​V. 36, № 1. — ​P. 228-240.

Zweig M.H. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine / M.H. Zweig, G. Campbell // Clinical Chemistry. — 1993. — ​V. 39, № 4. — P. 561-577.




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