Efficacy of Entrop administration for the treatment of asthenia in patients with traumatic brain injury

L.L. Chebotariova, A.V. Muravskiy, O.S. Solonovych


Background. Assessment of Entrop efficacy (INN: Mono) for the treatment of asthenia in patients with a traumatic brain injury. Materials and methods. Sixty patients with traumatic brain injury were examined in the interim and long-term periods after the trauma. Entrop was administered to 30 patients of the 1st (main) clinical group. Piracetam was administered as a nootropic drug to 30 patients of the 2nd (control) clinical group. The following methods were used: clinico-neurological; neuropsychological testing with the use of scales for the assessment of cognitive and asthenic disorders; neurophysiological — cognitive auditory evoked potentials (CAEP P300), digital EEG. Results. Within 1–1.5 months since the beginning of treatment with Entrop the incidence of asthenia symptom manifestation: general weakness, fatigue, irritability, emotional instability, memory impairment, diffidence, anxiety decreased significantly (p < 0.05); the values of latency and amplitude (CAEP P300) had a clear tendency for normalization. Conclusions. Entrop administration in patients with trauma brain injury led to a significant reduction of asthenic syndrome manifestations, improvement of cognitive functions according to the neuropsychological testing and objective neurophysiological indices — parameters of cognitive evoked potentials. The positive anti-asthenic effect of Entrop in the patient population in the study occurred earlier and in a larger number of patients than in the group treated with Piracetam.


traumatic brain injury; asthenic syndrome; Entrop


N.Yu. Bachynsraja, V.A. Holyn, K.N. Poletaeva. Peculiarities of Entrop application under syndrome of moderate cognitive impairments (Russian) // Ukrainian neurological journal 2009; 105: 1: 87-96.

V.I. Borodin, T.U. Kulikov, V.K. Bochkaryov, A.Z. Faysulloeva, F.S. Budtueva. New possibilities of noothropic therapy of asthenic disorders (Russian). http://conmed.ru/magazines/psikhiatriya_i_psikhofarmakoterapiya_im_p_b_ganushkina/psikhiatriya_i_psikhofarmakoterapiya_im_p_b_ganushkina-06-2006.

A.A. Vorobyova Asthenic conditions: effective and safe therapy (Russian). http://www.rmj.ru/articles/nevrologiya/Astenicheskie_sostoyaniya__effektivnaya_i_bezopasnaya_terapiya/#ixzz4GXhht7OC.

Yu.I. Golovchenko, R.Ya. Adamenko. Nootropic treatment of asthenia sindrom (Russian) // International neurological journal 2005; 4(4).

Yu.I. Goransky, V.N. Gerzev. Asthenic syndrome in traumatic brain injury as a reflection of autonomic dysfunction (Russian) // International neurological journal 2016; 4(82).

V.V. Zaharov. The use of Phenotropil in cognitive disorders of various etiologies (Russian) // Recept 2008; 4(60): 131-135.

V.V. Zaharov. Neuropsychological tests. The need for and the possibility of using (Russian) // Consilium medicum 2012; Vol.13, N2: 82-90.

Ju. D. Kropotov. Quantitative EEG, event related potentials and neurotherapy (English) ISBN 9780123745125. — Gardners Books2010600.

G.M. Kushnir, A.A. Mikljaev. Treatment of asthenia sindrom in ambulatory practice (Russian) // International neurological journal 2015; 2(40): 38-42.

B.V. Mykhaylov, E.I. Kudinova, O.V. Korshnyak. Effectiveness of Fenilpiratsetam (Entrop) in the treatment of patients asthenia neurotic and organic (posttraumatic) genesis (Russian) // Ukrainian journal psychoneurology 2014; 22: 3(80): 164-170.

A.YU. Savchenko, N.S. Zakharova, I.N. Stepanov. The phenotropil treatment of the consequences of brain organic lesions (Russian) // Zh Nevrol Psikhiatr Im SS Korsakova 2005; 105: 12: 22-26.

T.L. Vizilo, I.V. Vlasova. E.N. Kharkova, A.D. Vizilo, A.G. Chechenin, E.A. Polukarova. Traumatic encephalopathy: clinic and treatment (Russian) // Lvrach.ru 2016; 5: 28–33.

V.V. Zaharov. Neuropsychological tests. The need for and the possibility of using (Russian) // Consilium medicum 2012; Vol.13, N2: 82-90.

A.V. Muravskiy, L.L. Chebotariova, O.S. Solonovych // Clinical and neurophysiological characteristic boxers with repeated brain injury (Ukrainian) // International neurological journel 2015; 4(74): 37-45.

DOI: https://doi.org/10.22141/2224-0713.7.85.2016.86914


  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2017


 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru