Efficacy of Entrop administration for the treatment of asthenia in patients with traumatic brain injury

L.L. Chebotariova, A.V. Muravskiy, O.S. Solonovych


Background. Assessment of Entrop efficacy (INN: Mono) for the treatment of asthenia in patients with a traumatic brain injury. Materials and methods. Sixty patients with traumatic brain injury were examined in the interim and long-term periods after the trauma. Entrop was administered to 30 patients of the 1st (main) clinical group. Piracetam was administered as a nootropic drug to 30 patients of the 2nd (control) clinical group. The following methods were used: clinico-neurological; neuropsychological testing with the use of scales for the assessment of cognitive and asthenic disorders; neurophysiological — cognitive auditory evoked potentials (CAEP P300), digital EEG. Results. Within 1–1.5 months since the beginning of treatment with Entrop the incidence of asthenia symptom manifestation: general weakness, fatigue, irritability, emotional instability, memory impairment, diffidence, anxiety decreased significantly (p < 0.05); the values of latency and amplitude (CAEP P300) had a clear tendency for normalization. Conclusions. Entrop administration in patients with trauma brain injury led to a significant reduction of asthenic syndrome manifestations, improvement of cognitive functions according to the neuropsychological testing and objective neurophysiological indices — parameters of cognitive evoked potentials. The positive anti-asthenic effect of Entrop in the patient population in the study occurred earlier and in a larger number of patients than in the group treated with Piracetam.


traumatic brain injury; asthenic syndrome; Entrop


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