Influence of Fetal Tissues Transplantation on Degenerative Processes in Dopaminergic Systems of Rat Brain Caused by Severe Traumatic Brain Injury

Authors

  • B.O. Baranenko State Institution «Institute of Neurosurgery named after acad. A.P. Romodanov of National Academy of Medical Sciences of Ukraine», Kyiv, Ukraine

DOI:

https://doi.org/10.22141/2224-0713.8.62.2013.86117

Keywords:

traumatic brain injury, fetal nervous tissue, transplantation, dopamine, apoptosis

Abstract

The authors investigated dopamine and homovanillic acid contents and level of Bax gene expression in the left and right hemisphere cortexes, hypothalamus, hippocampus, striatum and midbrain of rats in 30 days after an experimental severe traumatic brain injury and fetal nervous tissue transplantation. It is found that severe traumatic brain injury leads to the decline of dopamine content in the striatum, hypothalamus and left (damaged) hemisphere cortex, as well as to the increase of proapoptotic Bax gene expression level in all investigated brain structures, that testifies to destructive processes in the brain of animals in a remote period after the injury. Fetal nervous tissue transplantation to experimental rats with severe traumatic brain injury provided the normalizations of investigated indexes.

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Published

2013-11-01

Issue

No. 8.62 (2013)

Section

Original Researches

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