Changes in the Concentration of Vitamin D in the Blood Serum of Patients with Multiple Sclerosis as a Pathogenetic Factor of This Disease

Authors

  • L.B. Orynchak Ivano-Frankivsk Regional Clinical Hospital Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine

DOI:

https://doi.org/10.22141/2224-0713.8.62.2013.86082

Keywords:

multiple sclerosis, etiology, pathogenesis, vitamin D

Abstract

According to current data, multiple sclerosis develops in people with a genetic predisposition to autoimmune diseases under the influence of environmental factors that also include a lack of vitamin D. The article presents the pathogenetic mechanisms of vitamin D influence on the development of multiple sclerosis. There were considered the changes in the concentration of vitamin D in the blood serum of 68 surveyed patients with multiple sclerosis, compared to apparently healthy individuals, depending on sex, age, duration of disease.

References

Вертегел А.О., Овчаренко Л.С. Остеогенез і імунні процеси в дітей / А.О. Вертегел, Л.С. Овчаренко // Здоровье ребенка. — 2009. — № 4(19). — С. 10-15.

Евтушенко С.К. и др. Новые возможности в терапии рассеянного склероза // Международный неврологический журнал. — 2006. — № 35. — С. 34-42.

Квашніна Л.В., Оніськова О.В. Забезпеченість вітаміном D та ризик розвитку захворювань серцево-судинної системи / Л.В. Квашніна, О.В. Оніськова // Современная педиатрия. — 2011. — № 5(39). — С. 61-64.

Комісаренко Ю.І., Антоненко О.В. Рівень вітаміну D і його зв’язок із вмістом глікованого гемоглобіну у хвори на цукровий діабет мешканців м. Києва // Ендокринологія. — 2012. — Т. 17, № 2. — С. 40-43.

Левченко І.Л. Гендерні особливості надсегментарної вегетативної регуляції у хворих на рецидивуючий перебіг розсіяного склерозу // Медицина сьогодні і завтра. — 2011. — № 3(52). — С. 107-112.

Маличенко С.Б. Постменопаузальный симптомокомплекс: роль кальция и витамина D в профилактике и лечении клинических проявлений эстрогенного дефицита / С.Б. Маличенко // Диалог о здоровой жизни. — 2007. — № 3. — С. 2-4.

Поворознюк В.В., Балацька Н.І. Дефіцит вітаміну D у населення України та фактори ризику його розвитку / В.В. Поворознюк, Н.І. Балацька // Боль. Суставы. Позвоночник. — 2012. — № 4(08). — С. 5-11.

Шмидт Т.Е., Яхно Н.Н.. Рассеянный склероз: руководство для врачей / Шмидт Т.Е., Яхно Н.Н. — 2-е изд. — М.: МЕДпресс-информ, 2010. — С. 20-21.

Ascherio A. Vitamin D and multiple sclerosis / A. Ascherio, K.L. Munger , K.C. Simon // Lancet Neurol. — 2010 Jun. — 9(6). — Р. 599-612.

Goris A., Pauwels I., Dubois B. Progress in multiple sclerosis genetics // Curr. Genomics. — 2012 December. — 13(8). — Р. 646–663.

Michael P. Chu, Kannayiram Alagiakrishnan, Cheryl Sadowski. The cure of ageing: vitamin D-magic or myth? // Postgrad. Med. J. — 2010. — 86. — P. 608-616.

Tabarkiewicz J., Bartosik-Psujek H., Pocinska K. Immunomodulatory effects of vitamin D on monocyte-derived dendritic cells in multiple sclerosis / J. Tabarkiewicz, H. Bartosik-Psujek, K. Pocinska // Multiple Sclerosis. — 2010 Nov 30. — 16(12). — Р. 1513-1516.

Downloads

Published

2013-11-01

Issue

No. 8.62 (2013)

Section

Original Researches

License

Copyright (c) 2016 INTERNATIONAL NEUROLOGICAL JOURNAL

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Our edition uses the copyright terms of Creative Commons for open access journals.

Authors, who are published in this journal, agree with the following terms:

  1. The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
  2. Directing  the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
  3. The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
  4. The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
  5. The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
  6. The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
  7. The rights to the article are deemed transferred by the authors to the edition (the publisher) since the moment of the publication of the article in the printed or electronic version of journal.