DOI: https://doi.org/10.22141/2224-0713.5.59.2013.85558

Peculiarities of Vascular Depressive Disorder at the Stages of Development of Subcortical Vascular Dementia in Old Age and Senility

O.A. Levada, I.Ya. Pinchuk

Abstract


The prevalence and clinical structure of vascular depressive disorders (VDD) have been studied in elderly patients at the stages of development of subcortical vascular dementia (SVD), its pathogenetic correlation with clinical manifestations of cognitive deficit, as well as impact of VDD on the daily functioning. There were examined 49 old and senile patients without cognitive impairments (WCI), 63 patients with subcortical vascular mild cognitive impairment (SVMCI) and 60 patients with SVD. VDD was a key psychopathological disorder at the stages of SVD development. Its prevalence increases with the deterioration of the cognitive status, and was 22.4 % in those WCI, 53.38 % — in patients with SVMCI and 70 % in patients with SVD. The special features of clinical structure of VDD in SVMCI and SVD were: moderate depression, greater cognitive component (attention disorders) and asthenic spectrum disorders, absence of suicidal symptoms, high comorbidity with apathy and impaired night and motor behavior. The combination of depressed apathetic and executive disorders suggests the formation of a specific syndromes of depressive-apathetic-executive dysfunction, progressing with the development stages of SVD. This group of symptoms affects the daily activities of patients. Severity of VDD in SVMCI and SVD depends primarily on the degree of leukoaraiosis and atrophic process of the frontal-subcortical parts of the brain according to MRI/CT data.

Keywords


vascular depressive disorder; subcortical vascular dementia; subcortical mild cognitive impairments

References


Agüero-Torres H., Fratiglioni L., Guo Z. et al. Dementia is the major cause of functional dependence in the elderly: 3-year follow-up data from a population-based study // Am. J. Public. Health. — 1998. — Vol. 88. — P. 1452-1456.

Lavretsky H., Zheng L., Weiner M.W. et al. Association of depressed mood and mortality in older adults with and without cognitive impairment in a prospective naturalistic study // Am. J. Psychiatry. — 2010. — Vol. 167. — P. 589-597.

Winter Y., Korchounov A., Zhukova T.V., Bertschi N.E. Depression in elderly patients with Alzheimer dementia or vascular dementia and its influence on their quality of life // J. Neurisci. Rural. Pract. — 2011. — Vol. 2. — P. 27-32.

Diniz B.S., Butters M.A., Albert S.M. et al. Late-life depression and risk of vascular dementia and Alzheimer’s disease: systematic review and meta-analysis of community-based cohort studies // Br. J. Psychiatry. — 2013. — Vol. 202. — P. 329-335.

Fatiglioni L., Launer L.J., Andersen K. et al. Incidence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts // Neurology. — 2000. — Vol. 54 (Suppl. 5). — S10-S15.

Jellinger K.A. The enigma of vascular cognitive disorder and vascular dementia // Acta Neuropathol. — 2007. — Vol. 113. — P. 349-388.

Ross G.W., Petrovitch H., White L.R. et al. Characterization of risk factors for vascular dementia: The Honolulu Asia Aging Study // Neurology. — 1999. — Vol. 53. — P. 337-343.

Chui H.С. Subcortical ischemic vascular dementia (SIVD) // Neurol. Clin. — 2007. — Vol. 25, № 3. — P. 717-740.

Castilla-Puentes R.C., Habeych M.E. Subtypes of depression among patients with Alzheimer’s disease and other dementias // Alzheimers Dement. — 2010. — Vol. 6, № 1. — P. 63-69.

Alexopoulos G.S. The vascular depression hypothesis: 10 years later // Biol. Psychiatry. — 2006. — Vol. 60, № 12. — P. 1304-1305.

Taylor W.D., Aizenstein H.J., Alexopoulos G.S. The vascular depression hypothesis: mechanisms linking vascular disease with depression // Mol. Psychiatry. — 2013 Feb 26. doi: 10.1038/mp.2013.20.

Erkinjuntti T., Inzitari D., Pantoni L. et al. Research criteria for subcortical vascular dementia in clinical trials // J. Neural. Transmission. — 2000. –Vol. 59(Suppl 1). — P. 23-30.

Cummings J.L., Mega M., Gray K. et al. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia // Neurology. — 1994. — Vol. 44. — P. 2308-2314.

Montgomery S.A., Asberg M.A. A new depression scale designed to be sensitive to change // Br. J. Psychiatry. — 1979. — Vol. 134. — P. 382-389.

Хомская Е.Д. Нейропсихология. — 4-е изд. — СПб.: Питер, 2005. — 496 с.

Folstein M.F., Folstein S.E., McHugh P.R. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician // J. Psychiat. Res. — 1975. — Vol. 12. — P. 189-198.

Morris J.C. The Clinical Dementia Rating (CDR): current version and scoring rules // Neurology. — 1993. –Vol. 43, № 11. — P. 2412-2414.

Bucks R.S., Ashworth D.L., Wilcock G.K., Siegfried K. Assessment of activities of daily living in dementia: development of the Bristol Activities of Daily Living Scale // Age Ageing. — 1996. — Vol. 25, № 2. — P. 113-120.

Терновой С.К., Дамулин И.В. Количественная оценка компьютерно-томографических характеристик головного мозга при нейрогериатрических заболеваниях // Мед. радиология. — 1991. — № 7. — С. 21-26.

Левин О.С. Клинико-магнитно-резонансно-томографическое исследование дисциркуляторной энцефалопатии с когнитивными нарушениями: Автореф. дис… канд. мед.наук. — М., 1996. — 24 с.

Oh D.H., Kim S.A., Lee H.Y. et al. Prevalence and correlates of depressive symptoms in korean adults: results of a 2009 korean community health survey // J. Korean Med. Sci. — 2013. — Vol. 28, № 1. — P. 128-135.

Göthe F., Enache D., Wahlund L.O. et al. Cerebrovascular diseases and depression: epidemiology, mechanisms and treatment // Panminerva Med. — 2012. — Vol. 54, № 3. — P. 161-170.

Lyketsos C.G., Steinberg M., Tschanz J.T. et al. Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging // Am. J. Psychiatry. — 2000. — Vol. 157. — P. 708-714.

Srikanth S., Nagaraja A.V., Ratnavalli E. Neuropsychiatric symptoms in dementia: frequency, relationship to dementia severity and comparison in Alzheimer’s disease, vascular dementia and frontotemporal dementia // J. Neurol. Sci. — 2005. — Vol. 236. —

P. 43-48.

Wang Y.Y., Chang Y.H., Lee S.Y. et al. Symptomatological and cognitive correlates of vascular comorbidity in older-elderly (at least 75 years old) men with major depressive disorder // Kaohsiung J. Med. Sci. — 2012. — Vol. 28, № 11. — P. 607-612.

Staekenborg S.S., Su T., van Straaten E.C. et al. Beha­vioural and psychological symptoms in vascular dementia; differences between small- and large-vessel disease // J. Neurol. Neurosurg. Psychiatry. — 2010. — Vol. 81. — P. 547-551.

Thomas P., Hazif Thomas C., Billon R. et al. Depression and frontal dysfunction: risks for the elderly? // Encephale. — 2009. — Vol. 35, № 4. — P. 361-369.

Rajkowska G., Miguel-Hidalgo J.J., Dubey P. et al. Prominent reduction in pyramidal neurons density in the orbito-

­frontal cortex of elderly depressed patients // Biol. Psychiatry. — 2005. — Vol. 58, № 4. — P. 297-306.




Copyright (c) 2016 INTERNATIONAL NEUROLOGICAL JOURNAL

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2018

 

   Seo анализ сайта