Parameters of Blink Reflex in the Periods of Motor Fluctuations in Parkinson’s Disease

O.A. Alenikova, S.A. Likhachev


The aim of the present work was to study the changes in the parameters of blink reflex in patients with motor fluctuations in Parkinson’s disease during on or off periods. Blink reflex was tested for hardware complex Nicolet Biomedical (USA), session VIKING. Latent period and amplitude of the R1 and R2 components of response were evaluated. It is found that blink reflex parameters are dynamic and depend on the phase of the action of DOPA-containing preparations. Three types of changes of blink reflex parameters in on/off periods were revealed, depending on the leading clinical syndrome. Probably, the change in pain threshold is a predisposing factor for the increase in polysynaptic reflex excitability. Increase or decrease of latency and amplitude of the main components of blink reflex under the influence of DOPA-containing preparations reflects the functional state of the segmental apparatus of the brain stem and descending regulatory effects of suprasegmental structures in Parkinson’s disease.


Parkinson’s disease; blink reflex; motor fluctuations


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