Differential Diagnosis of Parkinson’s Disease and Multiple System Atrophy

Ye.A. Trufanov

Abstract


The purpose of this study was the selection and description of the key differential diagnostic features and criteria for multiple system atrophy and Parkinson’s disease in order to improve the diagnosis and differential diagnosis of these diseases. A total of 205 patients with idiopathic Parkinson’s disease and 17 patients with multiple system atrophy had been examined. The severity of disease in patients with multiple system atrophy was significantly higher than in patients with Parkinson’s disease. Fall, freezing when walking, swallowing disorders, autonomic disorders, intellectual impairment, and depression occurred significantly more often in patients with multisystem atrophy compared with patients with Parkinson’s disease. Unlike Parkinson’s disease, in which the vast majority of cases (97.84 %) excellent, good or moderate effect of antiparkinsonian drugs was noted, in most patients with multiple system atrophy (73.33 %) only minor therapeutic effect was observed. Rapidly progressive autonomic dysfunction (not associated with any comorbidity) that developed shortly (1–2 years) before Parkinson’s disease, as well as onset of the disease with postural reflex impairment can be some of the distinctive features of multiple system atrophy.


Keywords


Parkinson’s disease; multiple system atrophy; differential diagnosis; progression

References


Нострант Т.Т. Дисфагия, боли в груди и гастроэзофагеальный рефлюкс / Т.Т. Нострант // Патофизиология органов пищеварения / Хендерсон Д.М. и др. — М.: Бином, 1997. — Глава 2. — С. 15-30.

Самосюк Н.И. Анатомия и физиология глотания, классификация нарушений глотания, диагностика дисфагии / Н.И. Самосюк // Нейрон Ревю. — 2011. — № 2. — С. 2-22.

A Validation Exercise on the New Consensus Criteria for Multiple System Atrophy / Y. Osaki, Y. Ben-Shlomo, A.J. Lees et al. // Movement Disorders. — 2009. — Vol. 24, № 15. — P. 2272-2276.

Epidemiology of multiple system atrophy. ESGAP Consortium. European Study Group on Atypical Parkinsonisms / N. Vanacore, V. Bonifati, G. Fabbrini et al. // Neurological Sciences. — 2001. — Vol. 22, № 1. — P. 97-99.

Flabeau O., Meissner W.G., Tison F. Multiple system atrophy: current and future approaches to management / O. Flabeau, W.G. Meissner, F. Tison // Therapeutic Advances in Neurological Disorders. — 2010. — Vol. 3, № 4. — P. 249-263.

Frequency of nocturnal sudden death in patients with multiple system atrophy / T. Shimohata, T. Ozawa, H. Nakayama // Journal of Neurology. — 2008. — Vol. 255, № 10. — P. 1483-1485.

Health-Related Quality of Life in Multiple System Atrophy / A. Schrag, F. Geser, M. Stampfer-Kountchev et al. // Movement Disorders. — 2006. — Vol. 21, № 6. — P. 809-815.

Quinn N.P. How to Diagnose Multiple System Atrophy / N.P. Quinn // Movement Disorders. — 2005. — Vol. 20, Suppl. 12. — P. S5-S10.

Quinn N.P. Multiple system atrophy — the nature of the best / N.P. Quinn // Journal of Neurology, Neurosurgery, and Psychiatry. — 1989. — Vol. 52, Special Suppl. — P. 78-89.

Quinn N.P. Multiple system atrophy / N.P. Quinn // Edited by C.D. Marsden, S. Fahn Movement Disorders. — London: Butterworth-Heinemann, 1996. — P. 262-281.

Second consensus statement on the diagnosis of multiple system atrophy / S. Gilman, G.K. Wenning, P.A. Low et al. // Neurology. — 2008. — Vol. 71, № 9. — P. 670-676.

Survival in Multiple System Atrophy / A. Schrag, G.K. Wenning, N. Quinn, and Y. Ben-Shlomo // Movement Disorders. — 2008. — Vol. 23, № 2. — P. 294-296.




DOI: https://doi.org/10.22141/2224-0713.3.57.2013.85413

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