Relationship between New Biomarkers of High Risk for Cerebrovascular Disease and the Severity of Neurological Deficit in Acute Ischemic Stroke

D.A. Filimonov


Recent studies have shown significantly increasing importance of new risk factors such as high levels of homocysteine and C-reactive protein, the presence of thrombophilia markers in the development of ischemic stroke. However, information of their relationship in acute ischemic stroke, especially in young patients is limited. The purpose of this study was to determine the impact of stroke high-risk biomarkers (activity of antithrombin III, ADP-induced platelet aggregation, fibrinogen, homocysteine, C-reactive protein) on neurological deficit in patients with acute ischemic stroke. It was found that the severity of neurological deficit correlated with fibrinogen levels (p = 0.031), C-reactive protein (p = 0.045) and low activity of antithrombin III (p = 0.039). In the subgroup of patients under 50 years a statistically significant effect of homocysteine level (p = 0.013) and ADP-platelet aggregation (p = 0.028) on the stroke severity was revealed. The study showed that the impact of biomarkers on the ischemic stroke severity is age-dependent, while at young age hyperhomocysteinemia is of great importance.


risk factors; ischemic stroke severity


Евтушенко С.К. Гетерогенный ишемический инсульт у детей / С.К. Евтушенко // Новости медицины и фармации. — 2010. — № 370. — С. 56-61.

Филимонов Д.А. Гипергомоцистеинемия как прокоагулянтный фактор риска у пациентов с атеротромботическим ишемическим инсультом и возможности лечебной коррекции /

Д.А. Филимонов // Нейронауки: теоретичні та клінічні аспекти. — 2012. — Т. 2, № 8. — С. 204-208.

Brobeck B.R. Pediatric stroke: The child is not merely a small adult // Neuroimaging Clin. N. Am. — 2005. — Vol. 15. — Р. 589-607.

Dadu R.T. Cardiovascular biomarkers and subclinical brain disease in the atherosclerosis risk in communities study / R.T. Dadu, M. Fornage, S.S. Virani, V. Nambi, R.C. Hoogeveen, E. Boerwinkle, A. Alonso, R.F. Gottesman, T.H. Mosley, C.M. Ballantyne // Stroke. — 2013. — Vol. 44. — Р. 1803-1808.

Grau A.J. Risk factors, outcome, and treatment in subtypes of ischemic stroke: the German stroke data bank / A.J. Grau, C. Weimar, F. Buggle, A. Heinrich, M. Goertler, S. Neumaier, J. Glahn, T. Brandt, W. Hacke, H.C. Diener // Stroke. — 2001. — Vol. 32. — Р. 2559-2566.

Guercini F. Cryptogenic stroke: time to determine aetiology / F. Guercini, M. Acciarresi // J. Thromb. Haemost. — 2008. — Vol. 6. — Р. 549-554.

Hankey G.J. Potential new risk factors for ischemic stroke: what is their potential? / G.J. Hankey // Stroke. — 2006. — Vol. 37. — Р. 2181-2188.

Kernagis D.N. Evolving role of biomarkers in acute cerebrovascular disease / D.N. Kernagis, D.T. Laskowitz // Ann. Neurol. — 2012. — Vol. 71, № 3. — Р. 289-303.

Luepker R.V. WHO MONICA project: what have we learned and where to go from here? / R.V. Luepker // Public Health Rev. — 2011. — № 4. — Р. 33.

Meng R. Antithrombin III associated with fibrinogen predicts the risk of cerebral ischemic stroke / R. Meng, Z.Y. Li, X. Ji, Y. Ding, S. Meng, X. Wang // Clin. Neurol. Neurosurg. — 2011. — Vol. 113. — Р. 380-386.

Perini F. Elevated plasma homocysteine in acute stroke was not associated with severity and outcome: Stronger association with small artery disease / F. Perini, E. Galloni, I. Bolgan, G. Bader, R. Ruffini, E. Arzenton, S. Alba, C. Azzini, L. Bartolomei, G. Billo, F. Bortolon,

P. Dudine, P.G. Garofalo, R. L’Erario, M. Morra, P. Parisen,

G. Stenta, V. Toso // Neurol. Sci. — 2005. — Vol. 26. — Р. 310-318.

Romero J.R. Stroke prevention: modifying risk factors / J.R. Romero, J. Morris, A. Pikula // Ther. Adv. Cardiovasc. Dis. — 2008. — Vol. 2. — Р. 287-303.

Roquer J. Endothelial dysfunction, vascular disease and stroke: The ARTICO study, 2009. — Р. 25-37.

Rundek T. Risk Factor Management to Prevent First Stroke // Neurol. Clin. — 2008. — Vol. 26. — Р. 1007-1045.

Saini M. Silent stroke: Not listened to rather than silent / M. Saini, K. Ikram, S. Hilal, A. Qiu, N. Venketasubramanian, C. Chen // Stroke. — 2012. — Vol. 43. — Р. 3102-3104.

Scarborough P. Stroke statistics 2009 edition // British heart foundation [Электронный ресурс]. — URL:

Vermeer S.E. Silent brain infarcts: a systematic review // Lancet Neurol. — 2007. — Vol. 6. — Р. 611-619.



  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2017


 Яндекс.МетрикаSeo анализ сайта Рейтинг