Vascular Endothelial Growth Factor 1 as a Predictor for Adverse Cardiovascular Events in Patients with Arterial Hypertension III Stage. The Results of One-Year Follow-up. Part II

A.Ye. Berezin, O.A. Lisovaya

Abstract


The aim of the study was to investigate the predictive value of serial measurements of circulating vascular endothelial growth factor 1 (VEGF) level in stage III hypertensive patients.
Materials and Methods. One hundred and two patients with mild to moderate arterial hypertension III stage within 3 weeks after ische-mic stroke were included into the study. Follow-up was 12 months with a 3 month intervals. The circulating VEGF-1 level was assessed at baseline and after six months. Clinical interviews were conducted every 3 months for 1 year after receiving blood samples. As a clinical point we determined follow cardiovascular outcomes: recurrent stroke or transient ischemic attack, ischemic heart disease, sudden death, diabetes mellitus, cardiovascular events, including chronic heart failure, and the need for hospitalization for these reasons.
Results. The analysis of obtained outcomes have shown that increased VEGF-1 concentration within six months after ischemic stroke has been positively associated with incidence of cardiovascular events, when compared with individuals without increased circulating levels of VEGF-1. Adjusted odds ratio for the occurrence of cumulative cardiovascular events in stage III hypertension patients with VEGF-1 at baseline more 403.57 pg/ml, when compared with lower concentrations of it was 4.11 (95% CI = 2.66–7.28; P = 0.001), and an increased sixth month circulating VEGF-1 over 450.15 pg/ml, when compared with lower concentrations of it was associated with adjusted odds ratio 5.46 (95% CI = 3.12–7.90; P = 0.001).
Conclusion. Circulating vascular endothelial growth factor 1 level is an independent predictor of one-year cumulative cardiovascular events in patients with stage III hypertension after cerebral ischemic stroke.


Keywords


vascular endothelial growth factor 1; ischemic stroke; arterial hypertension; serial measurements; clinical outcomes; predicted value

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DOI: https://doi.org/10.22141/2224-0713.6.68.2014.80768

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