Immunoglobulins and Steroids in the Treatment of Children with Refractory Epilepsy (Scientific Review and Personal Observations)

A.V. Voronova

Abstract


The scientific review presents the latest data on immunopathology of malignant forms of epilepsy in children. On the basis of in-depth analysis of current literature data the author substantiates the role of blood-brain barrier and autoimmune reactions in the blood and cerebrospinal fluid, and their influence on the frequency of attacks. A table with current cerebrospinal fluid biomarkers playing diagnostic and prognostic role in the course of hard to treat forms of epilepsy in children is given. Based on personal observations, the author substantiates the role of combined use of antiepileptic drugs, intravenous immunoglobulin G and corticosteroids to prevent epileptic encephalopathy in children.


Keywords


refractory epilepsy in children; immunopathology of blood and cerebrospinal fluid; biomarkers; Keppra; valproates; intravenous immunoglobulin G; corticosteroids

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DOI: https://doi.org/10.22141/2224-0713.5.67.2014.80684

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