Angiotensin-Converting Enzyme Gene Polymorphism and Angiotensin II Level in Acute Stroke

O.Ye. Dubenko, S.L. Kostyukovsky, A.Ye. Kostyukovskaya

Abstract


In order to study the prevalence of polymorphisms of angiotensin-converting enzyme gene and their influence on the clinical, anamnestic and morphological changes in patients with acute stroke in hypertension we examined 131 patients with ischemic and hemorrhagic stroke. Determination of I/D angiotensin-converting enzyme gene polymorphism was performed using polymerase chain reaction, and the content of angiotensin II in the serum by ELISA. The reliable dominance of homozygous DD genotype compared with II and ID genotypes was established. The presence of D-allele is associated with a higher incidence of vascular risk factors in history, greater severity of neurological deficit, higher parameters of blood pressure at the onset of a stroke, larger extent of a stroke focus and additional brain damage by silent lacunar infarctions. The presence of D-allele is associated with higher levels of angiotensin II in the blood at acute stroke, which correlates with high blood pressure and severity of the patients.


Keywords


ischemic stroke; hemorrhagic stroke; angiotensin-converting enzyme gene polymorphism; angiotensin II

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DOI: https://doi.org/10.22141/2224-0713.4.66.2014.80602

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