Pathogenetic Correction with Fingolimod of Disorders of Neurological and Neuropsychological Functions in Patients with Multiple Sclerosis
DOI:
https://doi.org/10.22141/2224-0713.1.63.2014.80496Keywords:
multiple sclerosis, treatment, fingolimodAbstract
The results of clinical and neuropsychological examination of 7 patients with multiple sclerosis and their dynamics during treatment with fingolimod are presented in the article. The impact of fingolimod on neurological deficit, cognitive disorders, fatigue syndrome severity and quality of life of patients with multiple sclerosis are discussed. We have made the conclusion about the expediency of using pathogenetic preparation fingolimod in the treatment of patients with multiple sclerosis.
References
Лященко Е.А. Препарат финголимод в рамках современного подхода к лечению больных рассеянным склерозом // Русский медицинский журнал. — 2011. — № 31. — www.rmj.ru.
Негрич Т.І., Євтушенко С.К., Сорокін Б.В., Москаленко М.А. Доказова база методів діагностики та лікування розсіяного склерозу // Міжнародний неврологічний журнал. — 2012. — № 5. — С. 215-222.
Столяров И.Д., Петров А.М., Ивашкова Е.В., Вотинцева М.В., Никифорова И.Г. Инновационный механизм действия препарата финголимод при рассеянном склерозе // Русский медицинский журнал. — 2011. — № 29. — www.rmj.ru.
Шмидт Т.Е. Финголимод (Гилениа) — новый пероральный препарат для лечения ремиттирующего рассеянного склероза // Русский медицинский журнал. — 2012. — № 8. www.rmj.ru.
Brinkmann V. Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology // Pharmacol. Ther. — 2007. — Vol. 115. — Р. 84-105.
Brinkmann V. FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system // Br. J. Pharmacol. — 2009. — Vol. 158 (5). — Р. 1173-1182.
Brinkmann V., Davis M., Heise C. et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors // J. Biol. Chem. — 2002. — Vol. 277. — Р. 21453-21457.
Cohen J.A., Barkhof F., Comi G., Hartung H.P. et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis // N. Engl. J. Med. — 2010. — Vol. 362 (5). — Р. 402-415.
Dominguez M., Casals D., Sabate M. еt al. Prediction of pharmacokinetic/pharmacodynamic behaviour in humans of LAS189913, a S1P1 receptors agonist, based on preclinical studies in three animal species // Mult.Scl. — 2010 — V. 16, suppl. 10, S 150. — P. 453.
Foster C.A., Mechtcheriakova D., Storch M.K., Balatoni B., Howard L.M., Bornancin F., Wlachos A., Sobanov J., Kinnunen A., Baumruker T. FTY720 rescue therapy in the dark agouti rat model of experimental autoimmune encephalomyelitis: expression of central nervous system genes and reversal of blood-brain-barrier damage // Brain Pathol. — 2009. — Vol.19 (2). — Р.254-266.
Hla T. Signaling and biological actions of sphingosine 1-phosphate // Pharmacol. Res. — 2003. — Vol. 47 (5). — Р. 401-407.
Hohlfeld R., Calabresi P., O’Connor P. et al. Оral fingolimod (FTY720) reduces relapse rate in patients previously treated with disease-modifying therapies for multiple sclerosis and in patients who are treatment naiv: subgroup analysis of data from a 24-month phase III study (FREEDOM) // J. Neurol. — 2010. — v.257, suppl.1, S21.- Р.76.
Kappos L. et al. A Placebo-controlled study of oral Fingolimod in relapsing MS // N. Engl. J. Med. — 2010. — Vol. 362. — Р. 387-401.
Kappos L., Calabresi P., O Connor P. et al. Oral fingalimod (FTY720) has consistent, beneficial effects on disability progression outcomes in relapsing multiple sclerosis: 24-month, placebo-controlled results from phase III FREEDOMS study // J.Neurol. — 2010. — v. 257, suppl. 1, S144. — P. 445.
Kim S., Steelman A.J., Zhang Y., Kinney H.C.,
Li J. Aberrant upregulation of astroglial ceramide potentiates oligodendrocyte injury // Brain Pathol, epub ahead of print. — 2011,
May 25.
Meno-Tetang G.M., Li H., Mis S. et al. Physiologically based pharmacokinetic modeling of FTY720 in rats after oral and intravenous doses // Drug Metab Dispos. — 2006. — Vol. 34. —
Р. 1480-7.
Downloads
Published
Issue
Section
License
Copyright (c) 2016 INTERNATIONAL NEUROLOGICAL JOURNAL

This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
- The rights to the article are deemed transferred by the authors to the edition (the publisher) since the moment of the publication of the article in the printed or electronic version of journal.