DOI: https://doi.org/10.22141/2224-0713.1.63.2014.80424

Clinical Features of Focal Cortical Dysplasias in Children

M.I. Sigatullina, Sh.Sh. Shamansurov, N.A. Mirsaidova, Kh.L. Relova

Abstract


The article deals with the studying the basic clinical features in children with focal cortical dysplasia (FCD), and an assessment of neurosurgical treatment efficiency. The clinical features of 30 patients aged from 2 months to 16 years with the diagnosis of brain FCD were analyzed, as well as an efficiency of pre- and postoperative observation of the patients after neurosurgical treatment was estimated. All patients with FCD were found to have refractory epileptic seizures, 22 patients (73 %) were operated. Neuroimaging data in 70 % patients with FCD completely corresponded to data of long video-EEG-monitoring and a clinical semiology of seizures that is good predictive criteria for carrying out purposeful antiepileptic therapy and operative treatment in a case of refractory seizures.

Keywords


focal cortical dysplasia; epilepsy; surgical treatment of epilepsy; children

References


Ватолин К.В., Милованова О.А., Пыков М.И., Чернышева Н.В. Клинический случай фокальной корковой дисплазии в младенчестве // Клиническая неврология. — 2011. — № 2. — С. 43-45.

Евтушенко С.К., Омельяненко А.А. Клиническая электроэнцефалография у детей. — Донецк: Донеччина, 2005. — 850 с.

Милованова О.А., Мосин И.М., Калинина Л.В., Ватолин К.В., Пыков М.И., Яркина О.С. Шизэнцефалия (обзор литературы и клинические наблюдения) // Неврологический журнал. — 2012. — Т. 16, № 3. — С. 18-23.

Петрухин A.C. Эпилептология детского возраста: Руководство для врачей / Под ред. проф. А.С. Петрухина. — М.: Медицина, 2000.

Barkovich J.A., Guerrini R, Kuzniecky R.I., Jackson J.D., Dobyns W.D. A developmental and genetic classification for malformations of cortical development: update 2012 // Brain. — 2012. — 1. — 22.

Alkuraya F.S., Cai X., Emery C., Mochida G.H., Al-Dosari M.S., Felie J.M. et al. Human mutations in NDE1 cause extreme microcephaly with lissencephaly // Am. J. Hum. Genet. — 2011. — 88. — 536-47.

Bakircioglu M., Carvalho O.P., Khurshid M., Cox J.J., Tuysuz B., Barak T. et al. The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis // Am. J. Hum. Genet. — 2011. — 88. — 523-35.

Barak T., Kwan K.Y., Louvi A., Demirbilek V., Saygi S., Tuysuz B. et al. Recessive LAMC3 mutations cause malformations of occipital cortical development // Nat. Genet. — 2011. — 43. — 590-4.

Bast T., Ramantani G., Seitz A., Rating D. Focal cortical dysplasia: prevalence, clinical presentation and epilepsy in children and adults // Acta Neurol. Scand. — 2006. — 113. — 72-81.

Blumcke I., Thom M., Aronica E., Armstrong D., Vinters H.V., Palmini A. et al. The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission // Epilepsia. — 2011. — 52. — 158-74.

Han C.-W., Min B.-W., Kim Y., Jeong E.-H., Park C.-S., Woo Y.-J. et al. Immunohistochemical analysis of developmental neural antigen expression in the balloon cells of focal cortical dysplasia // J. Clin. Neurosci. — 2011. — 18. — 114-8.

Hildebrandt M., Pieper T., Winkler P. et al. Neuropathological spectrum of cortical dysplasia in children with severe focal epilepsies // Acta Neuropathol. (Berl.). — 2005. — 110. — 1-11.

Tassi L., Garbelli R., Colombo N., Bramerio M., Lo Russo G., Deleo F., Milesi G., Spreafico R. Type I focal cortical dysplasia: surgical outcome is related to histopathology // Epileptic. Disord. — 2010. — 12. — 181-191.

Kahane P., Bartolomei F. Temporal lobe epilepsy and hippocampal sclerosis: lessons from depth EEG recordings // Epilepsia. — 2010. — 51 (suppl. 1). — 59-62.

Fauser S., Schulze-Bonhage A., Honegger J. et al. Focal cortical dysplasias: surgical outcome in 67 patients in relation to histological subtypes and dual pathology // Brain. — 2004. — 27. — 2406-2418.

Spreafico R., Blumcke I. Focal cortical dysplasias: clinical implication of neuropathological classification systems // Acta Neuropathol. — 2010. — 120. — 359-367.




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