DOI: https://doi.org/10.22141/2224-0713.3.73.2015.78344

Combined Therapy in Patients with Restless Legs Syndrome Associated with Diabetic Polyneuropathy

N.P. Tkachuk, V.A. Hryb

Abstract


The feasibility and efficacy of sedative and hypnotic drug containing zopiclone and a range of herbal drugs (motherwort, hops extract, mint oil) in combination with pramipexole in patients with diabetic polyneuropathy, comorbid with restless legs syndrome were examined. The study involved 46 patients with restless legs syndrome associated with diabetic polyneuropathy. Depending on the treatment, the patients have been divided into 2 groups: the first group included 24 patients, who used pramipexole 0.75 mg daily for 2 weeks; the second group consisted of 22 patients who were treated with pramipexole 0.75 mg and zopiclone in combination with sedative herbal means. A survey by the rating scale of the restless legs syndrome severity, Epworth sleepiness scale was carried out. Subjective sleep characteristics were assessed by valid questionnaires. It was found that combined administration of pramipexole and zopiclone reduces the number of movements during sleep, patient sleep time, the number of night-time awakenings; improves the quality of daily morning awakening and working efficiency.


Keywords


restless legs syndrome; diabetic polyneuropathy; zopiclone; pramipexole

References


Бузунов Р.В. Синдром беспокойных ног: Учебное пособие для врачей ФГБУ «Клинический санаторий «Барвиха» / Р.В. Бузунов, Е.В. Царева. — М., 2011. — 27 с.

Зарецкий М.М. Синдром беспокойных ног: недооцененная проблема и современные возможности фармакотерапии / М.М. Зарецкий, Н.М. Черникова // Новости медицины и фармации. — 2011. — № 10. — С. 18-19.

Московко С.П. Синдром неспокійних ніг в осіб старшого та похилого віку: недооцінений та недолікований «тіньовий» феномен / С.П. Московко, Л.Н. Желиба, Г.С. Московко // Нейро News. — 2011. — № 2(1). — С. 12-16.

Результаты российского мультицентрового исследования эффективности и безопасности мелаксена (мелатонин) для лечения нарушений сна у пациентов с хронической церебральной сосудистой недостаточностью / М.Г. Полуэктов, Я.И. Левин, А.Н. Бойко и др. // Журнал неврологии и психиатрии имени С.С. Корсакова. — 2012. — Т. 112, № 9. — С. 45-52.

Про затвердження протоколів надання медичної допомоги при цукровому діабеті 2 типу. Наказ Міністерства охорони здоров’я від 21.12.2012 № 1118. — К., 2012. — 245 с.

Allen R.P. Pregabalin versus pramipexole for restless legs syndrome / R.P. Allen // N. Engl. J. Mеdicine. — 2014. — № 21. — Р. 50-51.

Chokroverty S. Therapeutic dilemma for restless legs syndrome / S. Chokroverty // N. Engl. J. Medicine. — 2014. — № 7. — Р. 667-668.

Periodic leg movements are associated with reduced sleep quality in older men: the MrOS Sleep Study / D.M. Claman, S.K. Ewing, S. Redline et al. // J. Clin. Sleep Med. — 2013. — № 9(11). — Р. 1109-1117.

Comella C.L. Treatment of restless legs syndrome / C.L. Comella // Neurotherapeutics. — 2014. — № 11(1). — Р. 177-187.

Neurocognitive function in patients with idiopathic Restless Legs Syndrome before and after treatment with dopamine-agonist / A. Galbiati, S. Marelli, E. Giora et al. // International Journal of psychophysiology. — 2014. — № 14. — Р. 57-65.

The long-term treatment of restless legs syndrome / Willis-Ekbom disease: evidence-based guidelines and clinical consensus best practice guidance: a report from the International Restless Legs Syndrome Study Group / D. Garcia-Borreguero, R. Kohnen, M.H. Silber et al. // Sleep Medicine. — 2013. — № 14(7). — Р. 675-684.

Greco D. Restless legs syndrome and diabetes mellitus: an accidental association? / D. Greco // Recenti Prog. Medicine. — 2011. — № 102(5). — Р. 212-216.

Restless legs syndrome in patients with type 2 diabetes: effectiveness of pramipexole therapy / S.I. Harashima, A. Nishimura, T. Osugi et al. // BMJ Support Palliat. Care. — 2014. — № 5. — Р. 34-38.

Periodic Limbic Movement Disorder during Sleep as Diabetes-Related Syndrome? A Polysomnographic Study / M. Rizzi, M. Barrella, G.D. Kotzalidis et al. // ISRN Endocrinology. — 2011. — № 36. — Р. 203-207.

Efficacy and tolerability of pramipexole for the treatment of primaryrestless leg syndrome: a meta-analysis of randomized placebo-controlled trials / W. Zhang, Y. Wang, S.Y. Cong et al. // Neuropsychiatr Diseases Treatment. — 2013. — № 9. — Р. 35-43.




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