DOI: https://doi.org/10.22141/2224-0713.4.74.2015.78226

Influence of the Differentiated Therapeutic Approach on Bioelectrical Activity of the Brain in Patients with Parkinson’s Disease and Dyscirculatory Encephalopathy of Atherosclerotic and Hypertensive Origin with Parkinsonian Syndrome

T.V. Chernii

Abstract


The objective of our study was to evaluate the changes in clinical and neurological, neurophysiological, neurotransmitter predictors of bioelectrical activity of the brain in patients with Parkinson’s disease (PD) and dyscirculatory encephalopathy of atherosclerotic and hypertensive origin with parkinsonian syndrome before the start of drug treatment and during the causal treatment. More significant cholinergic system failure in the central nervous system (CNS) was detected in the group of patients with PD. Electroencephalographic parameters that characterize the acti-vity of dopaminergic system were reduced in both groups. Features of neurotransmitter deficiency predetermined the prescription of pathogenetic therapy. The use of selective dopamine receptor agonists and glutamate receptor blockers (original amantadine sulfate) is indicated to the patients from both groups. Inclusion in the treatment of Parkinson’s disease (group 1) and dyscirculatory encephalopathy with parkinsonian syndrome (group 2) of complexes of drugs: selective dopamine receptor agonist + original amantadine sulfate — increases the proportion of favorable res-ponses of the CNS.


Keywords


Parkinson’s disease; dyscirculatory encephalopathy of atherosclerotic and hypertensive origin; parkinsonian syndrome; quantitative electroencephalography; bioelectrical activity of the brain; neurotransmitter systems; types of central nervous system

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