Trazodone in the Treatment of Depression after Stroke

M.M. Oros, V.V. Luts, N.N. Adamcho

Abstract


The article deals with the problem of depression in patients who have had a stroke. Its relevance, prevalence in these patients is presented. The pathogenesis is described in detail. Regarding the treatment of post-stroke depression, it is emphasized that drug therapy should be considered as part of the rehabilitation process in all patients after stroke. According to FDA guidelines, one of the most appropriate drugs for the treatment of these patients suffering from post-stroke depression is trazodone. Trazodone is characterized by moderate inhibition of serotonin reuptake and strong blockade of serotonin receptors. In addition to antidepressive effect, it has a very good anxiolytic effect that is comparable with that of chlordiazepoxide and diazepam. Given the sedative properties and favourable effect on sleep structure, it is also used as a sedative, mainly when the use of benzodiazepine sleeping pills is associated with increased risk. Clinical studies from previous years show that due to combined effect on various groups of receptors, trazodone has much less severe side effects and rapid therapeutic response.


Keywords


stroke; depression; treatment; trazodone

References


Александровский Ю., Барденштейн Л., Аведисова А. Психофармакотерапия пограничных психических расстройств. — М.: ГЭОТАР-МЕД, 2005. — 250 c.

Вейн А.М., Вознесенская Т.Г., Голубев В.Л., Дюкова Г.М. Депрессия в неврологической практике. — М., 1998.

Гусев Е.И., Скворцова В.И. Ишемия головного мозга. — М.: Медицина, 2001.

Гусев Е.И., Гехт А.Б., Боголепова А.Н., Сорокина И.Б. Особенности депрессивного синдрома у больных, перенесших ишемический инсульт // Журнал неврологии и психиатрии им. С.С. Корсакова, приложение «Инсульт». — 2001. — Вып. 3. — С. 28-31.

Гехт А.Б., Сорокина И.Б., Боголепова А.Н., Гудкова А.А. Опыт применения иксела (милнаципрана гидрохлорида) в лечении постинсультной депрессии // Терапевтический архив. — 2003. — № 75(10). — С. 34-8.

Гехт А.Б., Боголепова А.Н., Сорокина И.Б. Депрессия после инсульта: опыт применения ципрамила // Журнал неврологии и психиатрии им. С.С. Корсакова. — 2002. — Т. 102, № 5. — С. 36-40.

Мосолов С.Н. Клиническое применение современных антидепрессантов. — СПб., 1995. — 565 с.

Смулевич А.Б., Козырев В.Н., Сыркин А.Л. Депрессии у соматических больных. — М., 1997. — 108 с.

Сорокина И.Б. Депрессия у больных ишемическим інсультом: автореф. дис… канд. мед. наук. — М., 2005.

Adams R.D., Victor M., Ropper A.H. Principles of neuro-logy. — Sixth edition. — 1997. — Ch. 24-27, 57. — P. 495-573, 1520-1543.

Andersen G., Vestergaard K., Lauritzen L. Effective treatment of poststroke depression with the selective serotonin reuptake inhibitor citalopram // Stroke. — 1994. — Vol. 25, 6. — 1099-1104.

Berg A., Palomaki H., Lehtihalmes M., Lonnqvist J., Kaste M. Poststroke depression in acute phase after stroke // Cerebrovasc. Dis. — 2001. — Vol. 12(1). — P. 14-20.

Black K.G. Diagnosing depression after stroke // South. Med. J. — 1995 Jul. — Vol. 88(7). — P. 699-708.

Brola W., Szafraniec L. Depression as a complication of stroke // Przegl. Lek. — 1996. — Vol. 53(9). — P. 690-2.

Charles E. Mortality and Poststroke Depression // Am. J. Psychiatry. — August 2004. — Vol. 161. — P. 1506.

Choi-Kwon S., Han S.W., Kwon S.U., Kang D.W., Choi J.M., Kim J.S. Fluoxetine treatment in poststroke depression, emotional incontinence, and anger proneness: a doubleblind, placebo-controlled study // Stroke. — 2006 Jan. — Vol. 37(1). — P. 156-61.

Colonna L., Reines E.H., Andersen H.F. Escitalopram is well tolerated and more efficacious than citalopram in long-term treatment of moderately depressed patients. Poster presented at the 3rd International Forum on mood and anxiety disorders, Monte Carlo, Monaco, November 27–30, 2002.

Diequez S., Staub F., Bruggimann L., Bogousslavsky J. Is poststroke depression a vascular depression? // J. Neurol. Sci. — 2004 Nov 15. — Vol. 226(1–2). — P. 53-8.

Erfurth A., Loew M., Wendler G., Floreanu A. Depressive disorders in neurologic rehabilitation: therapy with paroxetine // Psychiatr. Prax. — 2001 Jan. — Vol. 28(1). — P. 43-4.

Huff W., Ruhrman S., Sitzer M. Post-stroke depression: diagnosis and therapy // Fortschr. Neurol. Psychiatr. — 2001 Dec. — Vol. 69(12). — P. 581-91.

Iacoboni M., Padovani A., Piero D., Lezi G.L. Poststroke depression: relationships with morphological damage and cognitive over time // Int. J. Neurol. Sci. — 1995. — Vol. 16. — P. 209-215.

Gonzalez-Torrecillas J.L., Mendlewicz J., Lobo A. Effects of early treatment of poststroke depression on neuropsychological rehabilitation // Int. Psychogeriatr. — 1995 Winter. — Vol. 7(4). — P. 547-60.

Kauhanen M., Korpelainen J.T., Hiltunen P., Brusin E., Mononen H., Maatta R., Nieminen P., Sotaniemi K.A., Myllyla V.V. Poststroke depression correlates with cognitive impairment and neurological deficits // Stroke. — 1999 Sep. — Vol. 30(9). — P. 1875-80.

Kim J.S., Choi-Kwon S. Poststroke depression and emotional incontinence: correlation with lesion location // Neurology. — 2000 May 9. — Vol. 54(9). — P. 1805-10.

Labi M.L.C., Phillips T.F., Gresham G.E. Psychosocial disability in physically restored long-term stroke survivors // Arch. Phys. Med Rehabil. — 1980. — Vol. 61. — P. 561-5.

Lepola U.M., Loft H., Reines E.H. Escitalopram (10–20 mg/day) is effective and well tolerated in a placebo-controlled study in depression in primary care // Int. Clin. Psychopharrnacol. — 2003. — Vol. 18. — P. 211-217.

Mayo N.E., WoodDauphinee S., Cote R., Durcan L., Carlton J. Activity, participation, and quality of life 6 months poststroke // Arch. Phys. Med. Rehabil. — 2002 Aug. — Vol. 83(8). — P. 1035-42.

Muller-Spahn F., Hock C. Clinical presentation of depression in elderly // Gerontology. — 1994. — Vol. 40 (Suppl. 1). — P. 10-14.

Narushima K., Kosier J.T., Robinson R.G. Preventing poststroke depression: a 12-week double-blind randomized treatment trial and 21-month follow-up // J. Nerv. Ment. Dis. — 2002 May. — Vol. 190(5). — P. 296-303.

Nys G.M., van Zandvoort M.J., van der Worp H.B., de Haan E.H., de Kort P.L., Jansen B.P., Kappelle L.J. Early cognitive impairment predicts long-term depressive symptoms and quality of life after stroke // J. Neurol. Sci. — 2006 Sep 25. — Vol. 247(2). — P. 149-56.

Ouimet M.A., Primeau F., Cole M.G. Psychosocial risk factors in poststroke depression: a systematic review // Can. J. Psychiatry. — 2001 Nov. — Vol. 46(9). — P. 819-28.

Paolucci S., Antonucci G., Grasso M.G., Morelli D., Troisi E., Coiro P., De Angelis D., Rizzi F., Bragoni M. Post-stroke depression, antidepressant treatment and rehabilitation results. A casecontrol study // Cerebrovasc. Dis. — 2001. — Vol. 12(3). — P. 264-271.

Paradiso S., Robinson R.G. Gender differences in poststroke depression // J. Neuropsychiatry Clin. Neurosci. — 1998 Winter. — Vol. 10(1). — P. 41-7.

Pohjasvaara T., Leppavuori A., Siira I., Vataja R., Kaste M., Erkinjuntti T. Frequency and clinical determinants of poststroke depression // Stroke. — 1998 Nov. — Vol. 29(11). — P. 2311-7.

Ramasubbu R., Robinson R.G., Flint A.J., Kosier T., Price T.R. Functional impairment associated with acute poststroke depression: the Stroke Data Bank Study // J. Neuropsychiatry Clin. Neurosci. — 1998 Winter. — Vol. 10(1). — P. 26-33.

Ramasubbu R., Tobias R., Buchan A.M., Bech-Hansen N.T. Serotonin transporter gene promoter region polymorphism associated with poststroke major depression // J. Neuropsychiatry Clin. Neurosci. — 2006 Winter. — Vol. 18(1). — P. 96-9.

Robinson R.G., Morris P.L., Fedoroff J.P. Depression and cerebrovascular disease // J. Clin. Psychiatry. — 1990 Jul. — Vol. 51(Suppl. 26–31). — Discussion 32-3.

Sanchez C., Kreilgaard M. R-citalopram ingibits functional and 5-HTP-evoked behavioural responses to the SSRI, escitalopram // Pharmacol. Biochem. Behav. — 2004. — Vol. 77. — P. 391-398.

Sato P., Bryan R.N., Fried L.P. Neuroanatomic and functional correlates of depressed mood: the Cardiovascular Health Study // Am. J. Epidemiol. — 1999. — Vol. 150. — P. 919-929.

Sandor H., Zsolt K., Harcos P., Nagy Z., Gyorgy N., Gyor-gy A. Clinical evaluation of the efficacy and safety of paroxetin in poststroke depression: results from a phase 4, open label, multicentre clinical trial with 26 weeks of follow-up // Orv. Hetil. — 2006 Dec 17. — Vol. 147(50). — P. 2397-404.

Schwartz J.A., Speed N.M., Brunberg J.A., Brewer T.L., Brown M., Greden J.F. Depression in stroke rehabilitation // Biol. Psychiatry. — 1993 May 15. — Vol. 33(10). — P. 694-9.

Shima S., Kitagawa Y., Kitamura T., Fujinawa A., Watanabe Y. Poststroke depression // Gen. Hosp. Psychiatry. — 1994 Jul. — Vol. 16(4). — P. 286-9.

Shimoda K., Robinson R.G. The relationship between poststroke depression and lesion location in long-term follow-up // Biol. Psychiatry. — 1999 Jan 15. — Vol. 45(2). — P. 187-92.

Spalletta G., Bossu P., Ciaramella A., Bria P., Caltagirone C., Robinson R.G. The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines // Mol. Psychiatry. — 2006 Nov. — Vol. 11(11). — P. 984-91. Epub 2006 Aug 8.

Staley J.K., Malison R.T., Innis R.B. Imaging of the serotonergic system: interactions of neuroanatomical and functional abnormalities of depression // Biol. Psychiatry. — 1998 Oct 1. — Vol. 44(7). — P. 534-49.

Varga D. Neuropsychiatric complications after stroke // Ideggyogy Sz. — 2002 Mar 20. — Vol. 55(3–4). — P. 128-36.

Verdelho A., Henon H. Depressive symptoms after stroke and relationship with dementia: a three-year follow-up study // Neuro-logy. — 2004 Mar 23. — Vol. 62(6). — P. 905-11.

Wiart L., Petit H., Joseph P.A., Mazaux J.M., Barat M. Fluoxetine in early poststroke depression: a double-blind placebo-controlled study // Stroke. — 2000 Aug. — Vol. 31(8). — P. 1829-32.

Williams L.S., Ghose S.S., Swinde R.W. Depression and other mental health diaognoses increase mortality risk after ische-mic stroke // Am. J. Psychiatry. — 2004 Jun. — Vol. 161(6). — P. 1090-5.

Whyte E., Mulsant B. Post stroke depression: epidemiology, pathophysiology, and biological treatment // Biol. Psychiatry. — 2002 Aug 1. — Vol. 52(3). — P. 253.

Yamakawa Y., Satoh S., Sawa S., Ohta H., Asada T. Efficacy of milnacipran on poststroke depression on inpatient rehabilitation // Psychiatry Clin. Neurosci. — 2005 Dec. — Vol. 59(6). — P. 705-10.




DOI: https://doi.org/10.22141/2224-0713.6.76.2015.78088

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 INTERNATIONAL NEUROLOGICAL JOURNAL

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru