Neuropsychological Characteristics of Depression in Patients with Rheumatoid Arthritis

О.V. Tkachenko, Yu.L. Naidenova


Introduction. Rheumatoid arthritis is one of the most frequent autoimmune rheumatic diseases. The presence of depressive symptoms along with severe rheumatic disease contributes to the risk of disability. Purpose. To study changes of neuropsychological performance of depression in patients with rheumatoid arthritis depending on duration and severity of the disease course. Material and methods. We have examined 60 young and middle aged persons, among whom 40 patients with rheumatoid arthritis and 20 were in a control group of healthy individuals. The average age amounted to 47.7 ± 10.8 years old. The patients with rheumatoid arthritis were divided into groups depending on the duration and course of the disease. All patients were undergone clinical and neurological examination, neuropsychological testing, clinical and laboratory, clinical and instrumental examinations. Results. Neuropsychological testing data indicated that among the patients with seropositive course gross depressive episode prevailed, unlike the patients of seronegative group, where the moderate depressive episode normally occurred. Thus in the patients with rheumatoid arthritis depression mostly manifested as a small depressive episode. Conclusion. Among the patients suffered from rheumatoid arthritis least than 10 years, the severity of depression had average degree of correlation, r = 0.69 and r = 0.66, both among seropositive and seronegative patients. With increasing disease duration and age of patients a trend to enhancement of the severity of the depression manifestations was observed.


rheumatoid arthritis; neuropsychological parameters; depression


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