DOI: https://doi.org/10.22141/2224-0713.5.75.2015.78051

Features of Trazodone in the Pathogenetic Therapy of Chronic Pain

B.O. Tsiurko, A.Yu. Pelepeichenko, D.V. Raskalei, H.V. Kaliuzhnyi, O.V. Makhynia

Abstract


The article considers the problem of the treatment of chronic pain syndrome. Among drugs recommended for such patients, antidepressants have a special place. Their effect is due to inhibition of amines, noradrenaline and serotonin in the central nervous system that consistently leads to increase in activity of antinociceptive system, increase in the pain threshold, mood modification, reduced pain. ­Attention is given to selective serotonin reuptake inhibitors and 5-HT2 receptor antagonist trazodone.


Keywords


chronic pain syndrome; treatment; antidepressants; trazodone

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