Features of Trazodone in the Pathogenetic Therapy of Chronic Pain

B.O. Tsiurko, A.Yu. Pelepeichenko, D.V. Raskalei, H.V. Kaliuzhnyi, O.V. Makhynia


The article considers the problem of the treatment of chronic pain syndrome. Among drugs recommended for such patients, antidepressants have a special place. Their effect is due to inhibition of amines, noradrenaline and serotonin in the central nervous system that consistently leads to increase in activity of antinociceptive system, increase in the pain threshold, mood modification, reduced pain. ­Attention is given to selective serotonin reuptake inhibitors and 5-HT2 receptor antagonist trazodone.


chronic pain syndrome; treatment; antidepressants; trazodone


Морозова О.Г., Ярошевский А.А. Нейропатическая боль: взгляд невролога // Новости медицины и фармации. Неврология. — 2010. — 339 (тематический номер).

Чистик Татьяна. Роль антидепрессантов в лечении хронического болевого синдрома // Новости медицины и фармации. Неврология. — 2012. — 420 (тематический номер).

Elena P. Calandre, Piedad Morillas-Arques, Rocнo Molina-Barea, Carmen M. Rodriguez-Lopez, Fernando Rico-Villademoros. Trazodone Plus Pregabalin Combination in the Treatment of Fibromyalgia // BMC Musculoskelet Disord. — 2011. — 12.

Frйdйrique Rodieux, Valйrie Piguet, Patricia Berney, Jules Desmeules, Marie Besson Personalized Medicine. Pharmacogenetics and Analgesic Effects of Antidepressants in Chronic Pain Management. — 2015. — 12 (2). — 163-175.

Lynda H. Oderda, Jason R. Young, Carl V. Asche, Ginette A. Psychotropic-Related Hip Fractures // Pepper The Annals of Pharmacotherapy. — 2012. — 46 (7). — 917-928.

Manish K. Singh, MD; Chronic Pain Syndrome Medication

Robert L. Barkin, MBA, Pharm D., Diana Barkin, Departments of Anesthesiology, Family Medicine, Pharmacology, and Psychiatry, Rush Medical College and The Rush Pain Center at Rush Presbyterian St. Luke's Medical Center, Chicago, Ill, and The Pain Center of Rush North Shore, Skokie, Ill // Pharmacologic Management of Acute and Chronic Pain: Focus on Drug Interactions and Patient-Specific Pharmacotherapeutic Selection South Med. J. — 2001. — 94 (8).


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2020


   Seo анализ сайта