Light Sensitivity of the Visual System as a Functional Biomarker of Neuronal Damage at Multiple Sclerosis in Patients with and without a History of Acute Optic Neuritis

O.I. Kubarko, N.P. Kubarko, Yu.O. Kubarko

Abstract


Objective — to evaluate contrast-color sensitivity of central vision, contrast-frequency sensitivity and dynamic visual acuity in healthy people, in healthy and sick eyes at multiple sclerosis (MS) in patients with and without a history of optic neuritis (ON). Material and methods. The study of visual function was performed for 150 eyes in 114 healthy people, 49 eyes of 36 patients with MS, who suffered an acute ON, and for 43 eyes of 29 MS patients without a history of ON. Assessment of static visual acuity, refraction and ophthalmoscopy of the eye fundus was performed in all patients before examining the indicators of light sensitivity. Results and conclusion. Based on the analysis of indicators of contrast-color sensitivity, contrast-frequency sensitivity and dynamic visual acuity, we have evaluated the changes in the light sensitivity of healthy and sick eyes in MS patients with and without a history of ON. It is found that the light sensitivity is reduced in healthy eyes of individuals with MS, who suffered monocular ON and that the reduction of light sensitivity in the eyes at MS in the presence of a history of ON is deeper. Light sensitivity remains reduced despite the recovery of static visual acuity after ON. Differences in the indices of light sensitivity of the visual system are used to discuss the relationship of acute demyelinating optic neuropathy with neuronal injuries and the nature of the course of multiple sclerosis. We also discuss the possibility of using the data about reduced light sensitivity for the early diagnosis and evaluation of neuronal disorders in the visual system in MS.


Keywords


multiple sclerosis; optic neuritis; light sensitivity; contrast-color sensitivity; contrast-frequency sensitivity; static and dynamic visual acuity

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DOI: https://doi.org/10.22141/2224-0713.4.82.2016.77695

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