Current Approaches to the Diagnosis of Herpesvirus Neuroinfections (Scientific Review)

D.V. Maltsev, S.K. Yevtushenko

Abstract


This article carefully considered the diagnostic capabilities of modern laboratory methods for verification of the diagnosis of human herpesvirus neuroinfections. The main known methods of laboratory diagnostics are divided based on 3 diagnostic levels depending on the informativeness and accuracy of their results. Modern diagnostics of herpesvirus neuroinfections is based on three reference points: the clinical picture of the disease, neuroimaging data and the results of laboratory methods to identify the virus. Thorough knowledge of clinical picture in herpesvirus lesions of the nervous system, including the characteristics of the main clinical forms of neuroinfection, enables to plan the rational algorithm of instrumental neuroimaging studies and to choose the suitable package of laboratory tests in each case. At the moment, there is no ideal laboratory method for verifying the diagnosis in herpesvirus lesions of the nervous system. A multiplex approach to the diagnosis of herpesvirus neuroinfections with simultaneous polymerase chain reaction of the liquor, comparative serological studies (calculation of the index of specific serum/cerebrospinal fluid IgG) and the determination of specific IgM in the cerebrospinal fluid is scientifically sound, which makes it possible to overcome the disadvantages of the various methods of laboratory diagnostics and to establish quickly the correct diagnosis even in difficult clinical situations.


Keywords


herpesviruses; neuroinfection; laboratory diagnostics

References


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DOI: https://doi.org/10.22141/2224-0713.3.81.2016.77618

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