Temporal Epilepsy: Morphological Substantiation of Psychoemotional Disorders
The most common psychopathological comorbid disorder in epilepsy is depression. We conducted a comprehensive examination of 80 patients with epilepsy. All the patients underwent neuroimaging and electroencephalography mapping. Beck and Spielberger-Khanin tests were used to assess a degree of severity of interictal depression and anxiety disorder. The presence of structural-metabolic disorders is important in the development of depression in patients with epilepsy. First of all, it is the deficit of corpus callosum, fornix and brain stem tracts that is registered when conducting a voxel-morphometry and diffusion tensor imaging. The findings indicate the presence of a larger deafferentation on the side of an epileptic focus. According to our results, psychoemotional disorders in epilepsy are associated with neurometabolic disorders in external parts of brain temporal lobes. The reduction of main peak amplitude P300, which is an objective characteristic of attention processes, correlates with metabolic process disorders in hippocampal structures. The combination of the cluster of a tractographic picture depletion in frontal parts and the cluster of the reduction of imaging brain commissures is the most unfavorable one in relation to developing cognitive and psychoemotional disorders in epilepsy. Modern neuroimaging techniques add more clinical criteria for epilepsy.
Berg A.T., Berkovic S.F., Brodie M.J., Buchhalter J. Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005–2009 // Epilepsia. — 2010. — Vol. 51, № 4. — P. 676-685.
Dudra-Jastrzebska M. et al. Mood disorders in patients with epilepsy // Pharmacological reports. — 2007. — Vol. 59. — Р. 369-378.
Evstigneev V.V., Kistsen V.V., Bulaev I.V., Sakovich R.A. The effect of structural white matter abnormalities on the clinical course of epilepsy // Adv. Clin. Exp. Med. — 2013. — Vol. 22, № 4. — P. 529-537.
Functional neuroimaging using the method 1H MRS in epilepsy / Lipatova L.V., Kapustina T.V. 1st Congress of the European Academy of Neurology (EAN) Berlin, Germany, 20–23 June 2015 // European Journal of Neurology. — 2015. — 22(Suppl. 1). — P. 631.
Hersdorffer D.C. et al. Psychopatology and Epilepsy: Is It the Chicken or the Egg? // Epilepsy Currents. — 2006. — Vol. 6, № 5. — Р. 147-149.
Kanner A.M. Depression and Epilepsy: A New Perspective on Two Closely Related Disorders // Epilepsy Currents. — 2006. — Vol. 6, № 5. — Р. 141-146.
Kimiskidis V.K. et al. Depression and anxiety in epilepsy: the association with demographic and seizure-related variables // Annals of General Psychiatry. — 2007. — Vol. 6. — Р. 28.
Yevtushenko S.K., Voronova A.V. Role of intrathecal synthesis of IgG in children with drug-resistant epilepsy // International Journal of Immunorehabilitation. — 2013. — Vol. 15(2). — P. 102-109.
Yevstigneiev V., Kistsen O., Sadokha K., Sakovich R. Epilepsy and migraine: neuroimaging and neuropathophysiological parallels // MNJ. — 2015. — № 1(71). — P. 12-18.
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