Temporal Epilepsy: Morphological Substantiation of Psychoemotional Disorders

V.V. Yevstyhnieiev, O.V. Kysten, L.V. Lipatova, R.A. Sakovych, T.V. Kapustyna

Abstract


The most common psychopathological comorbid disorder in epilepsy is depression. We conducted a comprehensive examination of 80 patients with epilepsy. All the patients underwent neuroimaging and electroencephalography mapping. Beck and Spielberger-Khanin tests were used to assess a degree of severity of interictal depression and anxiety disorder. The presence of structural-metabolic disorders is important in the development of depression in patients with epilepsy. First of all, it is the deficit of corpus callosum, fornix and brain stem tracts that is registered when conducting a voxel-morphometry and diffusion tensor imaging. The findings indicate the presence of a larger deafferentation on the side of an epileptic focus. According to our results, psychoemotional disorders in epilepsy are associated with neurometabolic disorders in external parts of brain temporal lobes. The reduction of main peak amplitude P300, which is an objective characteristic of attention processes, correlates with metabolic process disorders in hippocampal structures. The combination of the cluster of a tractographic picture depletion in frontal parts and the cluster of the reduction of imaging brain commissures is the most unfavorable one in relation to developing cognitive and psychoemotional disorders in epilepsy. Modern neuroimaging techniques add more clinical criteria for epilepsy.


Keywords


epilepsy; psychoemotional disorders; magnetic resonance diffusion tensor imaging with tractography; proton magnetic resonance spectroscopy

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DOI: https://doi.org/10.22141/2224-0713.2.80.2016.73982

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