Skeletal muscle damage in the course of coronavirus disease (COVID-19) in a pediatric practice. Own supervision: a clinical case


  • V.O. Svystilnyk Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine, Ukraine
  • O.S. Mihnusheva Kyiv City Pediatric Clinical Hospital 1, Kyiv, Ukraine, Ukraine
  • K.B. Savinova Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine, Ukraine



SARS-CoV-2, COVID-19, coronavirus disease, ske-letal muscle damage, rhabdomyolysis


Background. Coronavirus disease (COVID-19) pandemic is still at the heart of healthcare in Ukraine and over the world. The nervous system and other human organs and systems can be affected by pathogenic nature of SARS-CoV-2. We purposed to pay physicians’ attention to the diagnosis of skeletal muscle damage, in particular rhabdomyolysis, to avoid possible complications in COVID-19. Materials and methods. We have examined a group of children with skeletal muscle damage on the background of
COVID-19 during 2020–2021. A clinical case from own practice has been presented in the article. Results and conclusions. The patient, a 15-year-old boy, developed general weakness, severe pain in the right thigh and hip joint, fever 33 days after the acute phase of coronavirus disease. The differential diagnosis was carried out between skeletal muscle damage and osteomyelitis. Diffuse connective tissue diseases, oncohematological disorders, and hepatitis were excluded on the basis of clinical data and examinations. The inflammatory changes in m.iliopsoas, m.obturatorius internus and m.piriformis with abscess formation identified during clinical examination and magnetic resonance imaging, along with high levels of blood transaminases indicated the development of rhabdomyolysis. The detected positive IgG to SARS-CoV-2 confirmed the association of this pathological condition with the previous acute phase of COVID-19. Signs of coagulopathy, anemia in the hemogram simultaneously with the clinical symptoms of rhabdomyolysis confirmed the systemic lesions in the course of coronavirus disease in the child. Timely assessment of clinical symptoms (general weakness, muscle pain) and levels of creatine phosphokinase, transaminases, electrolytes, creatinine, blood urea will help make an early diagnosis of rhabdomyolysis, prescribe adequate therapy and prevent the deve-lopment of severe complications.


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Original Researches