Local application of non-steroidal anti-inflammatory drugs: advantages and disadvantages


  • A.V. Makogonchuk National Pirogov Memorial Medical University, Vinnytsia, Ukraine, Ukraine
  • Yu.O. Bezsmertnyi Research Institute for the Rehabilitation of Disabled People (Educational and Scientific Medical Center at the National Pirogov Memorial Medical University), Vinnytsia, Ukraine, Ukraine
  • L.Ye. Atamanchuk Research Institute for the Rehabilitation of Disabled People (Educational and Scientific Medical Center at the National Pirogov Memorial Medical University), Vinnytsia, Ukraine, Ukraine




nonsteroidal anti-inflammatory drugs, gel, dexketoprofen trometamol, treatment, review


The article presents literature data on the efficacy and safety of dexketoprofen trometamol gel when applied locally and comparative characteristics of this pharmacological agent with other transdermal forms of nonsteroidal anti-inflammatory drugs. It was found that dexketoprofen when applied topically in the form of a gel has a high ability to accumulate in the skin, muscle and nervous (neurons, myelin and hypothalamus) tissues which causes a good anti-inflammatory, anti-edema and analgesic effect of this drug. Dexketoprofen showed a low level of accumulation in the cartilage without stimulating degenerative changes in cartilage tissue, as it does not inhibit the synthesis of proteoglycans by chondrocytes. At the same time, dexketoprofen had a low capacity for accumulation in blood cells and in internal organs demonstrating a low pro-bability of systemic side effects.


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