Rasagiline: a second-generation MAO-B inhibitor for the treatment of Parkinson’s disease
Keywords:rasagiline, Parkinson’s disease, monotherapy, combination therapy, Unified Parkinson’s Disease Rating Scale
Parkinson’s disease is the second most common neurodegenerative disorder, affecting 1 to 2 % of people older than 60 years. Rasagiline is a potent and irreversible monoamine oxidase type B (MAO-B) inhibitor which has been approved for the treatment of Parkinson’s disease. Rasagiline inhibits MAO-B more potently than selegiline and has the advantage of once-daily dosing. In several large, randomized, placebo-controlled trials, rasagiline has demonstrated efficacy as monotherapy in early Parkinson’s disease and as adjunctive therapy in advanced Parkinson’s disease. Rasagiline has been shown to have disease-modifying, neuroprotective and anti-apoptotic effects. The data on its effectiveness in motor disorders in Parkinson’s disease and the rate of development of the effect against the background of its administration are presented. At the same time, taking rasagiline is not accompanied by serious adverse events, both with monotherapy and in combination with levodopa and dopamine agonists.
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