Clinical neuroimaging correlations in multiple sclerosis

Authors

  • R.K. Shiraliyeva Azerbaijan State Advanced Training Institute for Doctors named after A. Aliyev, Baku, Azerbaijan
  • A.H. Mirzayev Azerbaijan State Advanced Training Institute for Doctors named after A. Aliyev, Baku, Azerbaijan

DOI:

https://doi.org/10.22141/2224-0713.16.7.2020.218250

Keywords:

multiple sclerosis, brain atrophy, clinical features, correlation

Abstract

Background. The purpose was to study the correlation between morphometric indicators оf brain atrophy and clinical symptoms in multiple sclerosis (MS). Materials and methods. Eighty-eight patients (58 women, 30 men) with MS aged 18 to 60 years were under observation. Fifty-six patients had relapse-remitting multiple sclerosis (RRMS), 32 patients had a seconda-ry progressive multiple sclerosis (SPMS). All patients underwent magnetic resonance imaging with voxel-based morphometry. Results. A positive correlation (r = 0.44; p ˂ 0.01) was found between the duration of the disease and the degree of focal brain damage in RRMS; it was noted that the size of the foci increases with increasing duration of the disease. A similar relationship has been established in patients with SPMS. No correlation was found between the degree of focal brain damage in RRMS and SPMS, including the degree of disability with active foci absorbed by a contrasting substance. Conclusions. In MS patients, despite pronounced changes in white matter, the degree of disability depends on the severity of brain atrophy and is not related to the volume of focal lesion. There are significant relationships between morphometric indicators of atrophy of the gray and white matter of the brain and the degree of disability and functional impairment in RRMS and SPMS.

References

Гусев Е.И., Завалишин И.А., Бойко А.Н. Рассеянный склероз. М., 2011. 528 с.

Лорина Л.В., Буршинов А.О. Актуальные вопросы этиопатогенеза, клиники, диагностики и лечения рассеянного склероза (обзор литературы и собственные данные). Российский медико-биологический вестник имени академика И.П. Павлова. 2017. 25 (2). 316-327

Прахова Л.Н. Атрофия коры головного мозга при рассеянном склерозе. Журнал неврологии и психиатрии. 2014. 10 (2). 43-49.

Кротенкова М.В., Брюхов В.В., Морозова С.Н., Кротенкова И.А. Магнитно-резонансная томография в диагностике и дифференциальной диагностике рассеянного склероза: руководство для врачей. М.: ГЭОТАР-Медиа, 2019. 160 с.

Повереннова И.Е., Захаров А.В., Хивинцева Е.В. Мультимодальные вызванные потенциалы в диагностике активности течения рецидивирующе-ремиттирующего рассеянного склероза. Саратовский научно-медицинский журнал. 2018. 1. 157-160.

BinSawad A., Seoane-Vazquez E., Rodriguez-Monguio R. et al. Evalition of the Expanted Disability Status Scale and the Multiple Sclerosis Fubctional Composite as clinical andpoints in multiple sclerosis clinical trials: quantitative metaanalyses. Curr. Med. Res. Opin. 2016 Dec. 32 (12). 1-6. DOI: 10.1080/03007995.2016.1222516

Кротенкова И.А., Брюхов В.В., Переседова А.В., Кротенкова М.В. Атрофия центральной нервной системы при рассеянном склерозе: данные МРТ-морфометрии. Журнал неврологии и психиатрии им. С.С. Корсакова. 2014. 114 (10–2). 50-6.

Serag D., Ragab E. Bi-caudate ratio as a MRI marker of white matter atrophy in multiple sclerosis and ischemic leukocencephalopathy. Egypt. J. Radiol. Nucl. Med. 2019. 50. 99. https://doi.org/10.1186/s43055-019-0104-x

Bermel R.A. The measurement and clinical relevance of brain atrophy in multiple sclerosis. Lancet Neurol. 2006 Feb. 5 (2). 158-70. doi: 10.1016/S1474-4422(06)70349-0.

Oreja-Guevara C., Rovari S.M., Jannucci G. Progressive gray matter damage in panties with relapsing- remitting multiple sclerosis: a longitudinal diffusion tensor magnetic resonance imaging study. Arch. Neurol. 2005. 2 (4). 578-84.

Bö L., Geurts J.J., Vander Valk Р. et al. Lack of correlation between cortical demyelination and white matter pathologic changes in multiple sclerosis. Arch. Neurol. 2007. 64 (1). 76-80.

Вотинцева М.В., Минеев К.К., Петров А.М., Ильвес А.Г., Резникова Т.Н., Столяров И.Д. Связь когнитивных нарушений с локализацией очагов поражения белого вещества головного мозга у больных рассеянным склерозом. Журнал неврологии и психиатрии им. С.С. Корсакова. 2014. 114 (10–2). 57-60.

Шмидт Т.Е. Лечение рассеянного склероза и оптикомиелита [по материалам совместного конгресса американского и европейского комитетов по изучению рассеянного склероза. Сентябрь 2014, Бостон, США (2014 Joint ACTRIMS-ECTRIMS meeting (MSJ, 2014, V. 20, № S1)]. Неврологический журнал. 2015. 20 (2). 47-57.

Bermel R., İnnus M.D., Tjoa C.W., Bakshi R. Selective caudate atrophy in multiple sclerosis: a 3D MRJ pаrcelation study. Neuroreport. 2009. 14 (3). 335-339.

Steenwijk M.D., Daams M., Pouwels P.J. et al. Unraveling the relationship between regional gray matter atrophy and patho-logy in connected white matter tracts in long-standing multiple sclerosis. Hum. Brain Mapp. 2015. 36 (5). 1796-1807. doi: 10.1002/hbm.22738

Céline Louapre, Sindhuja T. Govindarajan, Costanza Giannì, Julien Cohen-Adad, Michael D. Gregory, A. Scott Nielsen, Nancy Madigan, Jacob A. Sloane, Revere P. Kinkel, Caterina Mainero. Is the Relationship between Cortical and White Matter Pathologic Changes in Multiple Sclerosis Spatially Specific? A Multimodal 7-T and 3-T MR Imaging Study with Surface and Tract-based Analysis. Radiology. February 2016. 278 (2). 524-535. doi: 10.1148/radiol.2015150486

Published

2020-10-01

Issue

Section

To practicing Neurologist