Quality of life characteristics in multiple sclerosis patients depending on the type of pain syndrome

Authors

DOI:

https://doi.org/10.22141/2224-0713.16.7.2020.218242

Keywords:

multiple sclerosis, pain, quality of life

Abstract

Background. Pain is one of the syndromes people with multiple sclerosis (MS) most often complained of. In many cases, pain remains underestimated by both doctors and patients, however, significantly affects patient’s quality of life. The purpose was to evaluate the quality of life characteristics in MS patients depending on the type of pain syndrome. Materials and methods. One hundred and four patients with MS who had complaints of pain during the previous month were examined. Each person was diagnosed with a type of pain syndrome. Then a survey was conducted using standardized questionnaires (Pain Detect, VAS, SF-36) and analysis of the quality of life characteristics of patients with different types of pain was carried out. Results. In MS patients with pain syndromes, low values of physical and psychological components of the quality of life were found in all types of pain. The most common types of pain syndromes were ongoing extremity pain, tension-type headache, painful tonic spasms and spasticity pain. The median indicators of the “Pain” characteristic were below 50 % in all types of pain, which demonstrates the impact of pain on the formation of the quality of life. The lowest values of the psychological component of the quality of life were in pain syndromes characterized by regular sudden high-intensity paroxysmal pain, namely Lhermitt’s phenomenon — 31.1 % [24.4; 45.9], migraine — 31.7 % [29.5; 39.1] and painful tonic spasms — 35.4 % [28.0; 40.2]. The lowest values of the physical component of the quality of life were in musculoskeletal pain induced by postural abnormalities — 25.4 % [24.8; 28.1]. The lowest value among the characteristics of the quality of life was in “Role limitations due to physical problems” characteristic — 9 out of 11 types of pain had a mean value of 0 %. Most quality of life scale indicators had higher values in patients with one type of pain than in people with 2–3 types of pain (p < 0.05). Thus, the mean value of the physical component of health was proved to be higher by 18.8 % (p = 0.004) in patients with one type of pain than in those with 2–3 types. In the psychological component, the difference between the groups was 4 % (p = 0.05). Conclusions. Pain syndromes, their type, characteristics and combination affect formation of the quality of life structure in people with MS. Adequate correction of pain syndromes, taking into account their type and characteristics, is an additional tool to improve the quality of life in patients with MS. Lowest values of the psychological component of the quality of life were found in pain syndromes, which are characterized by regular sudden high-intensity paroxysmal pain. The lowest value of the physical component of the quality of life was in patients with musculoskeletal pain induced by postural abnormalities. The presence of several types of pain in a patient with MS has a greater impact on the physical component of the quality of life.

References

Kratz AL, Braley TJ, Foxen-Craft E, Scott E, Murphy JF, Murphy SL. How Do Pain, Fatigue, Depressive, and Cognitive Symptoms Relate to Well-Being and Social and Physical Functioning in the Daily Lives of Individuals With Multiple Sclerosis? Arch Phys Med Rehabil [Internet]. 2017;98(11):2160–6. Available from: https://doi.org/10.1016/j.apmr.2017.07.004

Berkowitz AL. Global perspectives. Neurology. 2014;82(16):1463–4.

Foley PL, Vesterinen HM, Laird BJ, Sena ES, Colvin LA, Chandran S, et al. Prevalence and natural history of pain in adults with multiple sclerosis: Systematic review and meta-analysis. Pain [Internet]. 2013;154(5):632–42. Available from: http://dx.doi.org/10.1016/j.pain.2012.12.002

Heitmann H, Haller B, Tiemann L, Mühlau M, Berthele A, Tölle TR, et al. Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study. Pain. 2020;161(4):787–96.

Karamyan A, Sellner J. Journal Club: Effect of comorbidity on mortality in multiple sclerosis. Neurology. 2016;86(22):e228–30.

Barin L, Salmen A, Disanto G, Babačić H, Calabrese P, Chan A, et al. The disease burden of Multiple Sclerosis from the individual and population perspective: Which symptoms matter most? Mult Scler Relat Disord. 2018;25:112–21.

Truini A, Barbanti P, Pozzilli C, Cruccu G. A mechanism-based classification of pain in multiple sclerosis. J Neurol. 2013;260(2):351–67.

Nehrych OI, Pyrohova VI, Portnoy JG, Stimmel M, Foley FW, Nehrych TI. The Multiple Sclerosis Intimacy and Sexuality Questionnaire-19: validation and adaptation for Ukrainian population. Int Neurol J. 2019;0(5.107):19–25.

Algahtani HA, Shirah BH, Alzahrani FA, Abobaker HA, Alghanaim NA, Manlangit JS. Quality of life among multiple sclerosis patients in Saudi Arabia. Neurosciences. 2017;22(4):261–6.

Ysrraelit MC, Fiol MP, Gaitán MI, Correale J. Quality of life assessment in multiple sclerosis: Different perception between patients and neurologists. Front Neurol. 2018;8(JAN):1–6.

Nick ST, Robertsa C, Billiodeaux S, Davis DE, Zamanifekri B, Sahraian MA, et al. Multiple sclerosis and pain. Neurological Research. 2012; 34: 829-841;

Bozhenko M, Bozhenko N, Nehrych T. Features of trigeminal neuralgia in multiple sclerosis patients. J Neurol Sci. 2019;405:286–7.

Kobelt G, Eriksson J, Phillips G, Berg J. The burden of multiple sclerosis 2015: Methods of data collection, assessment and analysis of costs, quality of life and symptoms. Mult Scler J. 2017;23(2_suppl):4–16.

Published

2020-10-01

Issue

Section

Original Researches