Non-psychotic mental disorders in young men with epilepsy

Authors

  • A. Voitiuk Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
  • T. Litovchenko Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine

DOI:

https://doi.org/10.22141/2224-0713.16.6.2020.215139

Keywords:

epilepsy, comorbid disorders, non-psychotic mental disorders, neuropsychological testing, epilepsy in young men

Abstract

Background. Epilepsy is one of the most important clinical problems and at the same time it is an interdisciplinary challenge. Comorbid disorders in epilepsy represent an extensive heterogeneous group of various conditions, most of which are mental disorders (personality disorder, dementia, depression, anxiety disorders, psychoses). The objective is to study the comorbidity of epilepsy and non-psychotic mental disorders in young men and the characteristics of its impact on the quality of life of a patient. Materials and methods. This study analyzed data from neuropsychological testing of 40 men aged 18–44 years. The correlation analysis (Pearson correlation coefficient) was used to determine the degree and nature of the relationship between the study parameters. All the differences and relationships mentioned in the article were considered statistically valid at p < 0.05. Results. All patients in this study were found to have non-psychotic mental disorders in the form of anxiety, concern about their health, and a decrease in self-esteem. Personal and situational anxiety averaged 45.60 ± 0.35 points. One of the most common non-psychotic disorders in individuals with epilepsy is organic personality disorder. Analysis on the International Personality Disorder Examination scale showed that 32 people (80 %) had organic personality disorder due to epilepsy. The depression is the most common comorbidity observed in individuals with epilepsy. An analysis of the data of 40 people using Hamilton Depression Rating Scale showed that mild depressive disorders were observed in 18 (45 %) people, moderate — in 12 (30 %), and severe depressive disorders — in 10 patients (25 %). The depth of manifestations of depression correlated with the duration of the disease (r = 0.39; p < 0.05), introversion (r = 0.33; p < 0.05), age (r = 0.29; p < 0.05) and polytherapy (r = 0.53; p < 0.05). Conclusions. Thus, we have identified non-psychotic mental disorders such as organic personality disorder, dementia, depression, which are typical for epilepsy in young men.

References

Austin J.K., Harezlak J., Dunn D.W., Huster G.A. Behavior problems in children before first recognized seizures. Pediatrics. 2001. 107. 96-102.

Baker G. Quality of life of people with epilepsy: a European study. Epilepsia. 1997. 38(3). 353-362.

Barragan E., Cruz E., Urrutia M. Prevalence of attention deficit disorder in paediatric epilepsy patients. Epilepsia. 2006. 47(4). 179.

Barragan E., Cruz E., Urrutia M. Neurocognitive differences between frontal and temporal seizures in pediatric epilepsy. Epilepsia. 2006. 47(4). 206.

Broicher S.D., Kuchukhidze G., Grunwald T., Krämer G., Kurthen M., Jokeit H. “Tell me how do I feel” — emotion recognition and theory of mind in symptomatic mesial temporal lobe epilepsy. Neuropsychologia. 2012. 50(1). 118-128.

Folstein M.F., Folstein S.E., McHugh P.R. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 1975. 12(3). 189-198.

Gaitatzis A., Trimble M.R., Sander J.W. The psychiatric comorbidity of epilepsy. Acta Neurol. Scand. 2004. 110. 207-220.

Kanner A.M. Depression in epilepsy: prevalence, clinical semio-logy, pathogenic mechanisms, and treatment. Biol. Psychiatry. 2003. 54. 388-398.

Lodhi S., Agrawal N. Neurocognitive problems in epilepsy. Advances in Psychiatric Treatment. 2012. 18. 232-240.

Waxman S.G., Geschwind N. The interictal behavior syndrome of temporal lobe epilepsy. Arch. Gen. Psychiatry. 1975. 32. 1580-1586.

Глухова Л.Ю. Аутистический эпилептиформный регресс. Вест. эпилептол. 2012. 1. 3-11.

Евтушенко С.К. Разрушительные и труднокурабельные формы эпилепсии и эпилептические энцефалопатии. Междунар. неврол. журн. 2012. 6(52). 16-21.

Марценковський І.А. Протиепілептичні препарати та інші засоби лікування епілепсій з розладами спектра аутизму. Укр. вісн. психоневрол. 2014. 3(80). 121-126.

Марценковский И.А., Марценковская И.И. Эпилепсия и коморбидные расстройства психики и поведения. Укр. мед. ч­асопис. 2015. 4(108). 43-53.

Мищенко Т.С. Деменция — это не нозологическая форма, а синдром. Neuronews: Психоневрология и нейропсихиатрия. 2009. 2(1). 6-9.

Electronic source: http://www.moz.gov.ua

Downloads

Published

2020-09-01

Issue

Section

Original Researches