Effect of anticonvulsant drugs on men fertility


  • V.N. Hertsev Odessa National Medical University, Odesa, Ukraine
  • Yu.I. Goranskyi Odessa National Medical University, Odesa, Ukraine




epilepsy, antiepileptic drugs, fertility, men, sperm parameters, sex hormones, review


To study the world experience on the influence of antiepileptic drugs on sexual function and fertility in men and to find the drugs with the least negative impact on these functions, the search for the articles and abstracts in the MedLine, The Cochrane Library, Scopus, Google scholar databases was performed with such keywords as fertility, male fertility, men fertility, antiepileptic drugs, epilepsy, sex hormones, sperm parameters, sexual and reproductive health, sexual function. The analysis of the obtained data revealed that there is a relative lack of information on the effect of antiepileptic drugs on fertility in men, which necessitates further researches to study the influence of these drugs on the fertility of men, not just women. When prescribing antiepileptic drugs, in turn, it is desirable to give preference to drugs with the least negative impact on sexual function and fertility, such as levetiracetam, lamotrigine and oxcarbazepine.


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Original Researches