DOI: https://doi.org/10.22141/2224-0713.7.109.2019.183011

New pathogenetic aspects of the relationship between some risk factors of cerebrovascular diseases and Parkinson’s disease

V.N. Gertsev, A.N. Stoyanov, S.S. Mashchenko, S.A. Antonenko

Abstract


Role of the disorders of the autonomous nervous system in the development of cerebrovascular diseases and Parkinson’s disease is studied not enough until now. In a number of works it was found that diabetes, history of smoking, high blood pressure, increased level of glucose, cholesterol and triglycerides in the blood are considerably rarer observed in patients with idiopathic Parkinson’s disease. It is also reported about the reduced risk of stroke development in patients with Parkinson’s disease. At the same time, in other works it was found that the risk of stroke in patients with Parkinson’s disease increases, and diabetes and high blood pressure are associated with increased risk of developing this disease. It is also known that Parkinson’s disease and cardiovascular risk factors are independent factors for the development of cognitive disorders. Rеsults of works about the influence of statins on the onset and course of Parkinson’s disease are controversial. These contradictions partly can be explained by possible influence of fungal flora that, as known, is widely presented in patients with Parkinson’s disease. It is known that statins are produced by fungal microorganisms. Changes in the intestinal microbiota play a significant role in pathogenesis of Parkinson’s disease; gastrointestinal disorders in Parkinson’s disease are one of the first non-motor symptoms, which appear a few years before typical clinical presentation. In this case, small intestinal dysbiosis in most patients is associated with malabsorption due to high bacterial density. Thus, analyzing the above mentioned, it is possible to assume that intestinal and skin microbiota produces natural statins, and the use of antiparkinson and other drugs influences this function, that is why results of researches are contradictory. Studying etiopathogenesis of this relations requires further interdisciplinary researches on the base of evidential medicine. Perspective direction in the study of etiology and pathogenesis of Parkinson’s disease is a deep evaluation of the role of fungal microflora. A study of the relationships given above will allow us to identify new biomarkers and drug targets for the development of disease-modifying therapies.

Keywords


Parkinson’s disease; autonomous system; cerebrovascular disease; blood lipids; fungal microflora

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