Chronic low back pain is one of the most common causes of disability, both in our country and around the world. Often, acute low back pain is chronic and leads to disability. According to current concepts of chronic pain, the vicious circle begins to form during the period of subacute pain. Therefore, today the issue of managing patients in the subacute period is quite relevant. There are currently many studies showing the good effects of the use of antidepressants in the management of chronic pain, affecting peripheral-central and central mechanisms of pain, including serotonergic, noradrenergic and dopaminergic interactions. We conducted a study on the effectiveness of using duloxetine to prevent chronicity of low back pain. According to its results, for the treatment of pain syndrome and prevention of its chronicity in patients with subacute back pain, it is advisable to recommend the use of etodolac preparations: Etol Fort 800 mg/day in 2 divided doses, Etol SR 600 mg once a day, as well as combination therapy with addition of duloxetine antidepressant (Duxet 30–60 mg/day), especially in patients with severe anxiety.
Walker B.F. The prevalence of low back pain: a systematic review of the literature from 1966 to 1998. J. Spinal Disord. 2000. 13, 205-217.
Корж М.О. та ін. Поширеність транзиторного болю в спині серед харківських викладачів, науковців та студентів. Ортопедия, травматология и протезирование. 2014. № 1.
Chou R. Low Back Pain. Annals of Internal Medicine. 2014. 160(11). ITC6-1.
World Health Organization [Електронний ресурс]: Priority diseases and reasons for inclusion. Low back pain. URL: https://www.who.int.
Jasvinder Chawla. Low back pain and sciatica. Medscape. Aug 22, 2018.
Патофізіологія: підручник: у 2 т. Т. 2. Атаман О.В. Патофізіологія органів і систем. Вінниця: Нова книга, 2016. 448 с.: іл.
Castellsague J., Riera-Guardia N., Calingaert B. Individual NSAIDs and upper gastrointestinal complications: a systematic review and meta-analysis of observational studies (the SOS project). Drug Saf. 2012. № 35(12). P. 1127-1146.
ASAS recommendations for collecting, analysing and reporting NSAID intake in clinical trials — epidemiological stu-dies in axial spondyloarthritis. Ann. Rheum. Dis. 2011. 70 (2).
Copyright (c) 2019 INTERNATIONAL NEUROLOGICAL JOURNAL