The Multiple Sclerosis Intimacy and Sexuality Questionnaire-19: validation and adaptation for Ukrainian population

O.I. Nehrych, V.I. Pyrohova, J.G. Portnoy, M. Stimmel, F.W. Foley, T.I. Nehrych


Background. Sexual dysfunction is a common problem in women with multiple sclerosis (MS). The Multiple Sclerosis Intimacy and Sexuality Questionnaire­19 (MSISQ­19) is a specific instrument to evaluate sexual dysfunction in MS patients. The purpose of the study was to translate and validate the Ukrainian version of the MSISQ­19. Materials and methods. The original version of MSISQ­19 was translated under a standard procedure. A sample of 126 females with MS completed the questionnaire. Internal consistency was evaluated using Cronbach’s alpha. Convergent validity was established using correlation with the Multiple Sclerosis Quality of Life­54 (MSQOL­54) and the Expanded Disability Status Scale (EDSS). Results. Total scale reliability (Cronbach’s α = 0.943) and reliability for the primary (Cronbach’s α = 0.901), secondary (Cronbach’s α = 0.875), and tertiary subscales (Cronbach’s α = 0.918) were high. Disability level, measured with the EDSS, and quality of life, measured with the MSQOL­54, significantly correlated with MSISQ­19 total score. Both physical and mental health­related quality of life on the MSQOL­54 significantly correlated with MSISQ­19 total score, and with primary, secondary, and tertiary sexual dysfunction. Satisfaction with sexual function significantly correlated with MSISQ­19 total score, and with primary, secondary, and tertiary sexual dysfunction. Conclusions. The study findings suggest that the Ukrainian version of the MSISQ­19 is a reliable and valid instrument for sexual function assessment in Ukrainian women with MS. It can be used during routine counseling to introduce the theme of sexuality, to detect sexual dysfunction, provide treatment, and prevent the development of more severe problems and therefore preserve the proper quality of life for MS patients.


multiple sclerosis; Multiple Sclerosis Intimacy and Sexuality Questionnaire-19; sexual function

Full Text:



Harris, M. K., Maghzi, A. H., Etemadifar, M., Kelley, R. E., Gonzalez-Toledo, E., & Minagar, A. (2009). Acute demyelinating disorders of the central nervous system. Current treatment options in neurology, 11(1), 55. doi: 10.1007/s11940-009-0008-6

Voskuhl, R. R. (2002). Gender issues and multiple sclerosis. Current neurology and neuroscience reports, 2(3), 277-286. doi: 10.1007/s11910-002-0087-1

Kessler, T. M., Fowler, C. J., & Panicker, J. N. (2009). Sexual dysfunction in multiple sclerosis. Expert review of neurotherapeutics, 9(3), 341-350. doi: 10.1586/14737175.9.3.341

Tepavcevic, D. K., Kostic, J., Basuroski, I. D., Stojsavljevic, N., Pekmezovic, T., & Drulovic, J. (2008). The impact of sexual dysfunction on the quality of life measured by MSQoL-54 in patients with multiple sclerosis. Multiple Sclerosis Journal, 14(8), 1131-1136. . doi: 10.1177/1352458508093619

Nortvedt, M. W., Riise, T., Frugaård, J., Mohn, J., Bakke, A., Skår, A. B., ... & Myhr, K. M. (2007). Prevalence of bladder, bowel and sexual problems among multiple sclerosis patients two to five years after diagnosis. Multiple Sclerosis Journal, 13(1), 106-112. doi: 10.1177/1352458506071210

Foley, F. W., La Rocca, N. G., Sanders, A. S., & Zemon, V. (2001). Rehabilitation of intimacy and sexual dysfunction in couples with multiple sclerosis. Multiple Sclerosis Journal, 7(6), 417-421. doi: 10.1177/135245850100700612

McCabe, M. P., McDonald, E., Deeks, A. A., Vowels, L. M., & Cobain, M. J. (1996). The impact of multiple sclerosis on sexuality and relationships. Journal of sex research, 33(3), 241-248. doi: 10.1080/00224499609551840

Vermillion, S. T., & Holmes, M. M. (1997). Sexual dysfunction in women. Primary Care Update for OB/GYNS, 4(6), 234-240. doi: 10.1016/S1068-607X(97)00104-2

Christopherson, J. M., Moore, K., Foley, F. W., & Warren, K. G. (2006). A comparison of written materials vs. materials and counselling for women with sexual dysfunction and multiple sclerosis. Journal of Clinical Nursing, 15(6), 742-750. doi: 10.1111/j.1365-2702.2005.01437.x

Sanders, A. S., Foley, F. W., LaRocca, N. G., & Zemon, V. (2000). The multiple sclerosis intimacy and sexuality questionnaire-19 (MSISQ-19). Sexuality and Disability, 18(1), 3-26. doi: 10.1023/A:1005421627154

World Health Organization. Process of translation and adaptation of instruments. 2004. Available at: http://www.who .int/substance_abuse/research_tools/translation/en/ (accessed 30 March 2018).

Polman, C. H., Reingold, S. C., Banwell, B., Clanet, M., Cohen, J. A., Filippi, M., ... & Lublin, F. D. (2011). Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Annals of neurology, 69(2), 292-302. doi: 10.1002/ana.22366

Kurtzke, J. F. (1983). Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology, 33(11), 1444-1444. doi: 10.1212/WNL.33.11.1444

Vickrey, B. G. (1995). Multiple sclerosis quality of life (MSQOL)-54 instrument. Los Angeles: University of California, Los Angeles.

Nappi, R. E., Cucinella, L., Martella, S., Rossi, M., Tiranini, L., & Martini, E. (2016). Female sexual dysfunction (FSD): Prevalence and impact on quality of life (QoL). Maturitas, 94, 87-91. doi: 10.1016/j.maturitas.2016.09.013

Hayes, R., & Dennerstein, L. (2005). The impact of aging on sexual function and sexual dysfunction in women: A review of population‐based studies. The journal of sexual medicine, 2(3), 317-330. doi: 10.1111/j.1743-6109.2005.20356.x


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2020


   Seo анализ сайта