Clinical and neurological course and neuroaminoacids levels in patients with long-term consequences of the mild brain traumatic injury

Ye.V. Lekomtseva


We investigated 38 patients (11 women, 28.94 % and 27 men, 71.06 %) aged from 26 and 58 years with long-term consequences of the mild brain traumatic injury; mean age 43.61 ± 8.24 years. The neuroaminoacids (glutamate, aspartate, γ-aminobutyric acid) blood serum concentration was measured by spectrophotometer method to study their pathogenetic influence on the forming of long-term consequences of the mild brain traumatic injury. It was shown that the patients with long-term consequences of the mild brain traumatic injury with mild brain contusion in their anamnesis (39.48 %) had the prominent changing in neuroaminoacids content, namely high glutamate serum level (246.25 ± 21.39 μmol/l vs controls 112.75 ± 11.72 μmol/l) and decreased γ-aminobutyric acid serum level (2.10 ± 1.16 μmol/l vs controls 6.72 ± 1.59 μmol/l). The forming of long-term consequences of the mild brain traumatic injury was accompanied by vegetative malregulation manifesting in parasympathetic tendency of the vegetative tonus determined in many patients of the first group (78.26 %) and in 86.67 % patients in the second group, that also may play a significant role in the disease pathogenesis and may have important clinical and prognostic value in further development of traumatic encephalopathy. All these findings need to be accounted into consideration during the treatment of this category of patients.


long-term consequences of the mild brain traumatic injury; glutamate; aspartate; γ-aminobutyric acid; vegetative tonus


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