Antiepileptic drugs therapy in children with comorbidity of epilepsy and autism spectrum disorders

A.I. Kudlatch, L.V. Shalkevich, O.S. Litvinova


Background. The article discusses the use of antiepileptic drugs in children with comorbidity of autistic spectrum disorders and epilepsy (or subclinical epileptiform discharges on the electroencephalogram). Materials and methods. To study the results of antiepileptic drugs prescription in this group of patients an original approach is used. It is based on the comparison of anamnestic, clinical and electroencephalographic data with the main and additional symptoms of autism spectrum disorders. Results. The efficacy of antiepileptic drugs for correction of neurological and mental state has been revealed. The normalization of muscle tone and coordination, reduction of motor stereotyped movements and sensory perception abnormalities, as well as improvement of speech and ability to communicate, decrease of aggression level, increase of intelligence quotient, and normalization of sleep were statistically established. Conclusions. Due to the analysis of antiepileptic drugs effectiveness, an approach to the treatment of autistic symptoms in comorbid patients is planned.


children; autism spectrum disorders; autism; epilepsy; antiepileptic drugs; cognitive functions; behavioral functions


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