DOI: https://doi.org/10.22141/2224-0713.6.100.2018.146459

Association of susceptibility weighted imaging and mild parkinsonian signs in patients with small vessel disease

M.S. Petrenko

Abstract


Background. Mild parkinsonian signs (MPS) can occur as a result of neurodegenerative diseases, cerebral small vessel disease (SVD) or manifest as a consequence of these two processes that occur simultaneously. Objective of this study was to identify whether there is a correlation between changes in magnetic susceptibility of subcortical brain structures and the presence of mild parkinsonian signs in patients with SVD. Materials and methods. Eighty two elderly participants with SVD and without known neurodegenerative diseases were included in this analysis and underwent magnetic resonance imaging: T1­weighted imaging, T2­weighted imaging, turbo inversion recovery magnitude, diffusion­weighted imaging, susceptibility weighted imaging (SWI) sequences. Presence of MPS was detected with the help of the third section of the Unified Parkinson’s Disease Rating Scale. Results. Using Mann­Whitney U test it was found that patients with MPS had statistically higher subcortical structure susceptibility rates and thus they had higher counts of hypointense voxels on the SWI. 3D Slicer Software was used to perform subcortical structure segmentation according to the signal intensity rates. In patients with MPS, more hypointense voxels were found in globus pallidus, putamen and substantia nigra of both hemispheres. After adjusting for age and the Fazekas score, MPS were most associated with an increased number of severe hypointensity voxels (signal intensity < 75) in right globus pallidus: odds ratio 1.29, confidence interval 1.08–1.55. Conclusions. Increased hypointensity of subcortical structures detected using SWI may be associated with MPS in patients with cerebral small vessel disease.


Keywords


parkinsonian symptoms; subcortical structures; magnetic resonance imaging

References


Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges // Lancet Neurol. — 2010. — Vol. 9, №7. — P. 689-701. — doi: 10.1016/S1474-4422(10)70104-6.

Свиридова Н.К. Когнітивні та емоційно-особистісні порушення у хворих на гіпертензивну енцефалопатію. Стан мозкового кровообігу при артеріальній гіпертензії (науковый огляд та особисті спостереження) / Н.К. Свиридова // Міжнародний неврологічний журнал. — 2016. — № 1. — С. 123-130.

Hatate J., Miwa K., Matsumoto M., Sasaki T., Yagita Y., Sakaguchi M., Kitagawa K., Mochizuki H. Association between cerebral small vessel diseases and mild parkinsonian signs in the elderly with vascular risk factors // Parkinsonism Relat. Di­sord. — 2016. — Vol. 26. — P. 29-34. — doi: 10.1016/j.parkreldis.2016.02.011.

de Laat K.F., van Norden A.G., Gons R.A., van Uden I.W., Zwiers M.P., Bloem B.R., van Dijk E.J., de Leeuw F.E. Cerebral white matter lesions and lacunar infarcts contribute to the presence of mild parkinsonian signs // Stroke. — 2012. — Vol. 43, № 10. — P. 2574-2579. — doi: 10.1161/STROKEAHA.112.657130.

Louis E.D., Bennett D.A. Mild Parkinsonian signs: An overview of an emerging concept // Mov. Disord. — 2007.— Vol. 22. — P. 1681-1688. — doi:10.1002/mds.21433.

Louis E.D., Schupf N., Manly J., Marder K., Tang M.X., Mayeux R. Association between mild parkinsonian signs and mild cognitive impairment in a community // Neurology. — 2005. — Vol. 64, № 7. — P. 1157-61. — doi: 10.1212/01.WNL.0000156157.97411.5E.

Van der Holst H.M., van Uden I.W.M., Tuladhar A.M. et al. Cerebral small vessel disease and incident parkinsonism: The RUN DMC study // Neurology. — 2015. — Vol. 85, № 18. — P. 1569-1577. — doi: 10.1212/WNL.0000000000002082.

Rosso, Andrea L. et al. Vascular and dopaminergic contributors to mild parkinsonian signs in older adults // Neuro­logy. — 2018. — Vol. 90, № 3. — P. 223-229. — doi: 10.1212/WNL.0000000000004842.

Acosta-Cabronero J., Betts M.J., Cardenas-Blanco A., Yang S., Nestor P.J. In vivo MRI mapping of brain iron deposition across the adult lifespan // J. Neurosci. — 2016. — Vol. 36, № 2. — P. 364-374. — doi: 10.1523/JNEUROSCI.1907-15.2016.

Liu C., Li C., Yang J., Gui L., Zhao L., Evans A. C. et al. Characterizing brain iron deposition in subcortical ischemic vascular dementia using susceptibility-weighted imaging: an in vivo MR study // Behav. Brain Res. — 2015. — Vol. 288. — P. 33-38. — doi: 10.1016/j.bbr.2015.04.003.

Gupta D., Saini J., Kesavadas C. et al. Utility of susceptibi­lity weighted MRI in differentiating Parkinson’s disease and atypical parkinsonian syndromes // Neuroradiology. — 2010. — Vol. 52. — P. 1087-94.

van Norden A.G., de Laat K.F., Gons R.A., van Dijk E.J. et al. Causes and consequences of cerebral small vessel disease. The RUN DMC study: a prospective cohort study. Study rationale and protocol // BMC Neurol. — 2011. — Vol. 11, № 1. — P. 29. — doi: 10.1186/1471-2377-11-29.

Mahlknecht P., Kiechl S., Stockner H., Willeit J., Gasperi A., Poewe W., Seppi K. Predictors for mild parkinsonian signs: A prospective population-based study // Parkinsonism and Related Disorders. — 2015. — Vol. 21, № 3. — P. 321-324.

de Laat K.F., van Norden A.G.W., van Oudheusden L.J.B., van Uden I.W.M., Norris D.G., Zwiers M.P., de Leeuw F.-E. Diffusion tensor imaging and mild parkinsonian signs in cerebral small vessel disease // Neurobiology of Aging. — 2013. — Vol. 33, № 9. — P. 2106-2112.

Haller S., Badoud S., Nguyen D. et al. Differentiation between Parkinson disease and other forms of Parkinsonism using support vector machine analysisof susceptibility-weighted imaging (SWI): initial results // Eur. Radiol. — 2013. — Vol. 23, № 1. — P. 12-19. — doi: 10.1007/s00330-012-2579-y.

He N., Ling H., Ding B., Huang J., Zhang Y., Zhang Z. et al. Region-specific disturbed iron distribution in early idiopathic Parkinson’s disease measured by quantitative susceptibility mapping // Hum. Brain Mapp. — 2015. — Vol. 36, № 11. — P. 4407-4420. — doi: 10.1002/hbm.22928.

Meijer F.J., van Rumund A., Fasen B.A., Titulaer I., Aerts M., Esselink R., Bloem B.R., Verbeek M.M., Goraj B. Susceptibility-Weighted Imaging Improves the Diagnostic Accuracy of 3T Brain MRI in the Work-Up of Parkinsonism // American Journal of Neuroradio­logy. — 2015. — Vol. 36, № 13. — P. 454-460. — doi: 10.3174/ajnr.A4140.

Rouault T.A. Iron metabolism in the CNS: implications for neurodegenerative diseases // Nat. Rev. Neurosci. — 2013. — Vol. 14. № 8. — P. 551-64. — doi: 10.1038/nrn3453.

Ward, Roberta J. et al. The role of iron in brain ageing and neurodegenerative disorders // The Lancet Neurology. — 2014. — Vol. 13, № 10. — P. 1045-1060. — doi:10.1016/S1474-4422(14)70117-6.

Buchman A., Leurgans E.S., Nag S., Bennett D., Schneider J. Cerebrovascular Disease Pathology and Parkinsonian Signs in Old Age // Stroke. — 2011. — Vol. 42, № 11. — P. 3183-9. — doi: 10.1161/STROKEAHA.111.623462.

Zijlmans J.C., Daniel S.E., Hughes A.J., Révész T., Lees A.J. Clinicopathological investigation of vascular parkinsonism, includingclinical criteria for diagnosis // Mov. Disord. —2004. — Vol. 19. — P. 630-640.

Louis E.D., Brickman A.M., DeCarli C., Small S.A., Mar­der K., Schupf N. et. al. Quantitative brain measurements in community dwelling elderly persons with mild parkinsonian signs // Arch. Neurol. — 2008. — Vol. 65, № 12. — P. 1649-1654. — doi: 10.1001/archneurol.2008.504.




Copyright (c) 2018 INTERNATIONAL NEUROLOGICAL JOURNAL

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2018

 

   Seo анализ сайта