Bone mineral density, fat and lean mass in stroke patient

M.А. Bystrytska


Background. Stroke and osteoporosis is an age­dependent pathology that affects elderly people mostly. The purpose of the study was to evaluated bone mineral density (BMD), fat mass, lean mass and their relationship in stroke patients. Materials and methods. We examined 84 stroke patients and 124 persons of the corresponding age and sex without neurological pathology, who made up the comparison group. BMD, fat mass and lean mass were determined using dual­energy X­ray absorptiometry. Results. The frequency of osteoporosis was significantly higher in stroke men and women than in the comparison group (12.5 versus 1.7 % and 20.5 versus 6.0 %, respectively). BMD in stroke women was significantly lower at all level observed, in men differences were recorded at distal radius and in the total body. The lean mass was significantly lower in stroke men (54.29 ± 1.22 and 58.02 ± 0.85 kg; p < 0.05), and the fat mass was significantly lower (32.42 ± 1.92 and 36.71 ± 1.15 kg; p < 0.05) in stroke women in comparison with control group. The men of both groups showed positive correlation between the BMD of the total body and the lean mass. Stroke women have positive relationships between fat mass and the BMD of the femoral neck, upper limbs, total body and significant correlation between fat mass and all regions of the skeleton. Conclusions. The results of our study show that stroke is a risk factor for the development of osteoporosis and emphasize the role of fat and lean mass in the development of osteoporosis in stroke patients.


osteoporosis; bone mineral density; fat mass; lean mass; stroke


Mishchenko TS. Epidemiology of cerebrovascular diseases and organization of care for patients with stroke in Ukraine. Ukrains'kyi visnyk psykhonevrolohii. 2017; 25 (01):22–24. (In Rusian).

Beaupre GS, Lew HL. Bone-density changes after stroke. Am J Phys Med Rehabil. 2006 May;85(5):464-72.

Schnitzer TJ, Harvey RL, Nack SH, Supanwanid P, Maskala-Streff L, Roth E. Bone mineral density in patients with stroke: relationship with motor impairment and functional mobility. Top Stroke Rehabil. 2012 Sep-Oct;19(5):436-43. doi: 10.1310/tsr1905-436.

Kapral MK., Fang J, Alibhai SM, Cram P, Cheung AM., Casaubon LK., Prager M., Stamplecoski M., Rashkovan B., Austin P.C. Risk of fractures after stroke: Results from the Ontario stroke registry. Neurology. 2017;88:57–64. doi: 10.1212/WNL.0000000000003457.]

Wei M, Haiyian L, Huo K., Su H*Impact of Bone Fracture on Ischemic Stroke Recovery. Int J Mol Sci. 2018 May; 19(5): 1533.. doi:  10.3390/ijms19051533

Huo K,  Syed IHL Y Yong K, Su H, Qu Q. Impact and risk factors of post-stroke bone fracture. World J Exp Med. 2016 Feb 20; 6(1): 1–8.  doi: 10.5493/wjem.v6.i1.1

Carda S, Cisari C,·Invernizzi M, Bevilacqua M. Osteoporosis after Stroke: A Review of the Causes and Potential Treatments. Cerebrovasc Dis 2009;28:191–200

Pluskiewicz W. Skeletal consequences in patients after stroke // Endokrynologia Polska. Polish Journal of Endocrinology, 2011; 62; (1). ISSN 0423–104X

Forster A, Young J. Incidence and consequences of falls due to stroke: a systematic inquiry. BMJ. 1995; 311: 83–86.

Moayyeri A, Luben RN, Wareham NJ, Khaw KT. Body fat mass is a predictor of risk of osteoporotic fractures in women but not in men: a prospective population study. J Intern Med. 2012 May;271(5):472-80. doi: 10.1111/j.1365-2796.2011.02443.x.

Sornay-Rendu E, Sornay-Rendu E, Duboeuf F, Boutroy S, Chapurlat RD Muscle mass is associated with incident fracture in postmenopausal women: The OFELY study. Bone. 2017; Jan; Pages 108-113.

NIH Stroke Scale Accessed June 30, 2018.

Official Positions 2015 ISCD (Adult & Pediatric). Accessed June 30, 2018.

Borschmann Karen Exercise Protects Bone after Stroke, or Does It? A Narrative Review of the Evidence // Stroke Research and Treatment

Volume 2012; 12; Article ID 103697, 12 p.

Kim, HD, Kim SH, Kim DK, Jeong HJ, Sim YJ, Kim GC. Change of Bone Mineral Density and Relationship to Clinical Parameters in Male Stroke Patients. Annals of Rehabilitation Medicine, 2016; 40(6), 981–988.

Povoroznyuk VV, Grigoriieva NV. Menopause and Musculoskeletal System. 2004, 512 p. (In Ukrainian).

Lazoura O, Groumas N, Antoniadou E, Papadaki PJ, Papadimitriou A, Thriskos P et al: Bone mineral density alterations in upper and lower extremities 12 months after stroke measured by peripheral quantitative computed tomography and DXA. J Clin Densitom 2008;11:511–517.

Hunnicutt JL, Gregory CM. Skeletal muscle changes following stroke: a systematic review and comparison to healthy individuals. Topics in Stroke Rehabilitation, 2017, 24(6): 463–471.

Lin CH, Chang WC, Kuo CN , Yu HC, Yang CC, Lin YW, Hung KS, Chang WP A population-based five-year study on the risk of stroke in patients with osteoporosis in Taiwan / Lin CH, // Bone 2015, 72: 9-13.


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