Rizatriptan in the control of migraine symptoms
AbstractMigraine is a neurovascular disorder that itself disturbs the life of a person, and, in addition, increases the risk of cardiovascular diseases and subclinical brain lesions. Important place in the treatment of migraine belongs to triptans, one of which is rizatriptan. During the administration of triptans, 84 % of patients were satisfied and reported that the treatment was effective, while the same value for the administration of non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, was 37 %, analgesics (including paracetamol) — 26 %, ergotamine — 47 %. It is not surprising that such data entailed the modification of therapeutic algorithms towards triptans. Rizatriptan is serotonin 5-HT1B/1D receptor agonist and shows antimigrenous action due to three main mechanisms: constriction of meningeal vessels, suppression of neurogenic inflammation, reduction of pain transmission. Rizatriptan better relieves headache and restores normal functioning during the first 2 hours of treatment, causes less number of relapses within 24 hours after taking the drug, better relieves pain if relapse occurs, compared to the standard reference drug — sumatriptan. The tolerability of both drugs was the same and clinically acceptable. Pharmacoeconomic analysis revealed the superiority of rizatriptan over ergotamine/caffeine, NSAIDs/analgesics and many other triptans. Rizatriptan has a good evidence base of efficacy and tolerability and continues to be the drug of choice in the treatment of migraine.
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