DOI: https://doi.org/10.22141/2224-0713.2.96.2018.130480

Characteristics of comorbid diseases in patients with multiple sclerosis depending on its onset

К.М. Hychka

Abstract


The article presents an assessment of concomitant diseases impact on the course of multiple sclerosis (MS) in patients before and after the onset of this disease. The study was conducted by analyzing the anamnestic data of 77 patients aged 19 to 58 years. The enrollment criterion was a definite diagnosis of multiple sclerosis in accordance with reviewed McDonald 2010 criteria that was combined with at least one comorbid disease. Statistical data processing was performed through Microsoft Excel and Statistica programs. Comparison of indices between the groups (in accordance with Student’s t criterion) and correlation analysis (with the calculation of Pearson product-moment coefficient of linear correlation) were performed. There was defined a significant difference between the age at the time of MS onset (t = 2.63; р < 0.05), age at the time of the onset of concomitant disease (t = 2.14; р < 0.05), duration of MS (t = 3.37; р < 0.01), duration of comorbid disease (t = 4.61; р < 0.01) among the patients with comorbid pathology occurred prior to MS onset and, accordingly, patients with concomitant disease identified over a certain time after MS debut. Patients with
comorbid disease occurred after the MS onset have Expanded Di­sability Status Scale score of 3.49 ± 0.14 points on the average which is higher (t = 2.25; р < 0.05) by 17.9 % compared to the group of patients with comorbid disease occurred before the MS beginning — 2.96 ± 0.19 points.


Keywords


comorbidity; multiple sclerosis; concomitant diseases

References


Lassmann H., Brück W., Lucchinetti C.F. The immunopathology of multiple sclerosis: anoverview // Brain Pathol. — 2007. —

Vol. 17. — P. 210-8. doi: 10.1111/j.1750-3639.2007.00064.x.

Негрич Т.І. Доказова база методів діагностики і лікування розсіяного склерозу / Т.І. Негрич, С.К. Євтушенко, Б.В. Сорокін, М.А. Москаленко // Міжнар. невролог. журн. — 2012. — № 5(51). —

С. 25-30.

Соколова Л.И. К вопросу о современных методах диагностики и лечения рассеянного склероза // Мед. вестник. — 2008. —

№ 1. — С. 28-32.

Волошина Н.П., Левченко І.Л. Фармакоекономічне обґрунтування патогенетичного лікування розсіяного склерозу //

Міжнар. невролог. журн. — 2006. — № 4. — С. 91-98.

Franklin M.A., Happe L.E., Dillman R., Marshal L.Z. Frequency and economic impact of comorbid cardiac conditions with multiple sclerosis l // JMCP. — 2014. — Vol. 20. — № 8. — Р. 795-799. doi: 10.18553/jmcp.2014.20.8.795.

Белялов Ф.И. Лечение внутренних болезней в условиях коморбидности / Белялов Ф.И. — Иркутск: РИО ИГМАПО, 2012. — 283 с.

Козловский В.Л. Дифференцированная фармакотерапия коморбидных тревожных и депрессивных состояний / Козловский В.Л. — СПб.: СПбНИПНИ им. В.М. Бехтерева, 2012. — С. 4-6.

Campbell-Scherer D. Multimorbidity: a challenge for evidence-based medicine / Campbell-Scherer D. // Evid. Based Med. — 2010. —

№ 15. — Р. 165-166. doi: 10.1136/ebm1154.

Comorbid chronic diseases, discordant impact on mortality in older people: a 14-year longitudinal population study / Caughey G.E., Ramsay E.N., Vitry A.I. та ін. // Community Health. — 2010. —

№ 64. — Р. 1036-1042.

Свиридова Н.К., Чуприна Г.М. Патогенез, клініка, діагностика та комплексне лікування інсомній різного ґенезу з використанням методів рефлексотерапії / Н.К. Свиридова,

Г.М. Чуприна // East European Journal of Parkinson’s Disease and Movement Disorders. — 2016. — Vol. 2. — № 1. — Р. 26-35.

Marrie R.A., Horwitz R.I., Cutter G. et al. Comorbi­dity delays diagnosis and increases disability at diagnosis in MS //

Neurorl. — 2009. — Vol. 72. — P. 117-124. doi: 10.1212/01.wnl.0000333252.78173.5f.

Marrie R.A., Rudick R., Horwitz R. et al. Vascular comorbi­dity is associated with more rapid disability progression in multiple sclerosis // Neurol. — 2010. — Vol. 74. — P. 1041-1047. doi: 10.1212/WNL.0b013e3181d6b125.

Warren S.A., Turpin K.V., Pohar S.L. et al. Comorbidity and health-related quality of life in people with multiple sclerosis //

Int. J. MS Care. — 2009. — Vol. 11. — P. 6-16.

Fromont A., Binquet C., Rollot F. et al. Comorbidities at multiple sclerosis diagnosis // J. Neurol. — 2013. — Vol. 260. — P. 2629-2637.

doi: 10.1007/s00415-013-7041-9.

Kang J.H., Chen Y.H., Lin H.C. Comorbidities amongst patients with multiple sclerosis: A population-based controlled study // Eur. J. Neurol. — 2010. — Vol. 17. — P. 1215-1219. doi: 10.1111/j.1468-1331.2010.02971.x.

Marrie R.A. A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis // Multiple Sclerosis Journal. — 2015. — Vol. 21(3). — Р. 318-331. doi: 10.1177/1352458514564491.

Fromont A., Binquet C., Rollot F. et al. Comorbidities at multiple sclerosis diagnosis // J. Neurol. — 2013. — Vol. 260. —

Р. 2629-2637. doi: 10.1007/s00415-013-7041-9.

Association between comorbidity and clinical characteristics of MS [Електронний ресурс] / R.A. Marrie, R. Horwitz, G. Cutter et al. // Acta neurol. Scand. — 2011. — Vol. 124. — Р. 135-141. —

Режим доступу до журн.: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394540/.

The risk of fracture in patients with multiple sclerosis:the UK general practice research database / M.T. Bazelier, T. van Staa, B.M.J. Uitdehaag et al. // Journ. of Bone and Mineral Res. — 2011. —

Vol. 26. — № 9. — Р. 2271-2279.

Prevalence and incidence of ischemic heart disease in multiple sclerosis: A population-based validation study [Електронний ресурс] / R.A. Marrie, B.N. Yu, S. Leung et al. // Multiple sclerosis and related disorders. — 2013. — № 2. — Р. 355-361. —

Режим доступу до журн.: http://dx.doi.org/10.1016/j.msard.2013.03.001.

A systematic review of the incidence andprevalence of cancer in multiple sclerosis [Електронний ресурс] / R.A. Marrie, N. Reider, J. Cohen et al. // Multiple Sclerosis Journal. — 2015. — Vol. 21. — Р. 294-304. — Режим доступу до журн.: http://msj.sagepub.com.




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