Efficiency and expediency of using naproxen in various clinical situations

I.Yu. Golovach


The review article presents evidence of the clinical efficacy of naproxen in the treatment of rheumatological patients. The modern concept of the rational and safe use of non-steroidal anti-inflammatory drugs (NSAIDs) involves achieving maximum efficiency together with the maximum reduction in the risk of complications, primarily from the cardiovascular and gastrointestinal systems. According to clinical studies, among all NSAIDs the lowest
risk of cardiovascular complications is noted for naproxen. Napro­xen belongs to the group of non-selective NSAIDs, has been actively used in clinical practice for more than 40 years and has won the trust of doctors as a reliable analgesic and anti-inflammatory drug. The therapeutic potential of naproxen has been proven in various clinical situations — from acute episodes of pain and inflammation and to the treatment of chronic pain syndrome in rheumatological practice. The article presents and analyzes randomized clinical trials that emphasize the clinical efficacy and safety of naproxen in acute gouty arthritis, acute injuries, osteoarthritis, rheumatoid arthritis and spondyloarthritis.


non-steroidal anti-inflammatory drugs; chronic pain syndrome; safety; efficacy; naproxen


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