DOI: https://doi.org/10.22141/2224-0713.8.94.2017.120700

Behavioral disorders in patients with dementia: clinical picture, diagnosis and treatment

O.O. Kopchak

Abstract


The review of the literature contains data on neuropsychiatric (non-cognitive) symptoms in various types of dementia, which are quite heterogeneous and in most cases unpredictable, affect the emotional sphere, perception and motor function of patients. Typical behavioral disorders associated with certain types of dementia are described. It is recommended to combine non-pharmacological interventions with pharmacotherapy for patients with all types and different degrees of severity of dementia with concomitant non-cognitive symptoms. The therapeutic possibilities of various groups of drugs used for the treatment of behavioral disorders in dementia (cholinesterase inhibitors, NMDA receptors, anticonvulsants, antidepressants) were described in this review. According to current recommendations, the use of atypical antipsychotics should be avoided or, if necessary, minimized. From the position of evidence-based medicine, taking into account data of numerous clinical trials, there was found a significant efficacy of antidepressant with multimodal properties — trazodone in the treatment of behavioral disorders in dementia (irritability, agitation, anxiety, depressive disorders, insomnia and eating behavioral disorders).

Keywords


neuropsychiatric symptoms; dementia; treatment; review

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