The effectiveness of Cognifen in patients with cerebral ischemic hemispheric stroke in the late recovery period

A.A. Kozyolkin, L.V. Novikova, A.A. Dronova


The article presents the results of a study on the effectiveness of Cognifen in patients with cerebral ischemic hemispheric stroke in the late recovery period (from 6 to 12 months after the onset of stroke). We observed 60 patients with cerebral atherothrombotic (60.0 %) and cardioembolic (40.0 %) ischemic hemispheric stroke in the late recovery period. All patients were randomized by sex, age, stroke subtype, size of lesion focus and concomitant pathology. Patients with aphasic speech disorders, visual impairment (hemianopsia, metamorphopsia), concomitant somatic pathology in the stage of decompensation, uncontrolled hypertension, anamnestic data of craniocerebral trauma and alcohol abuse were not included in the study. The main observation group consisted of 30 patients who were taking Cognifen during 30 days in a comprehensive therapy, and control group included 30 patients who received the same medication (antiplatelet, anticoagulant, hypotensive, hypolipidemic, hypoglycemic drugs, etc.), physiotherapy, massage, exercise therapy, speech therapy correction, but without Cognifen. Detailed examination of clinical and neurological status was performed for all patients on the 1st and on the 30th day of the rehabilitation therapy. The assessment of the stroke severity was performed by the National Institutes of Health Stroke Scale, cognitive and psycho-emotional profile evaluated by the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Frontal Assessment Battery (FAB), memory for numbers methodology and by Patient Health Questionnaire-9. On the 30th day of therapy, an additional assessment of the disability degree was made according to the modified Rankin scale. By the 30th day of therapy, patients of the main observation group had a statistically significant difference in the total score on the MMSE, MoCA, FAB and on the memory for numbers method. Cognitive and psychoemotional profile among patients of the main observation group consisted in improvement of short-term visual memory, perceptive-gnostic sphere, attention and counting, delayed reproduction, fluency of speech, dynamic praxis and complicated choice reaction, patients also had marked regression of fatigue, sleep normalization, improvement of attention and interest.


ischemic stroke; late recovery period; cognitive impairment; psychoemotional disorders


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