Cell therapy in Parkinson’s disease: opportunities and challenges

M.Yu. Yurkevich, M.M. Zafranskaya, V.V. Ponomarev, A.V. Boiko, N.E. Aleinikova

Abstract


This review focuses on the main trends, opportunities and challenges of cell therapy application in Parkinson’s disease. During the past decades, countless experimental and clinical studies were held based on introducing various means of treatment parkinsonism, such as dopamine-producing cells, fetal brain tissue cells, genetically modified cells, as well as stem cells of different origin, including embryonic, neural, mesenchymal and induced pluripotent stem cells. While considerable progress has been made in this area, several practical aspects still require further consideration, including those involving ethical and technical factors, significant variability of the outcomes, side effects and oncological risks, as well as the need for induced neural differentiation protocol unification and compatibility.


Keywords


Parkinson’s disease; cell therapy; dopamine-producing cells; stem cells; genetically modified cells; review

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DOI: https://doi.org/10.22141/2224-0713.4.90.2017.107268

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